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BioWorld - Tuesday, April 21, 2026
Home » Topics » Clinical

Clinical
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AHA Scientific Sessions 2022

PROGRESSIVE-AF adds to the argument for ablation-first strategy for atrial fibrillation

Nov. 8, 2022
By Mark McCarty
Few disease states in the world of cardiology have been studied as persistently as atrial fibrillation (AF), but new study data presented in Chicago at the 2022 scientific sessions of the American Heart Association seem to advance the cause of an ablation-first strategy for some patients experiencing paroxysmal AF. The PROGRESSIVE-AF study demonstrated that patients who are ablated early in the disease cycle are less likely than those placed on drug management to experience recurrence and to be readmitted, just two of several findings that are driving cardiologists toward device therapy and away from drug therapy for their patients with AF.
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Medtronic - Symplicty Spyral HTN
AHA Scientific Sessions 2022

Medtronic’s Spyral HTN-ON MED trial reinforces evidence on meaningful clinical benefits

Nov. 8, 2022
By Meg Bryant
Medtronic plc reported six-month results from the full cohort of its Spyral HTN-ON MED study, showing a statistically significant reduction in office-based blood pressure, a key secondary endpoint. However, the trial missed its primary efficacy endpoint of a reduction in 24-hour systolic blood pressure, compared with a sham procedure.
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EU flag and light bulb

EFPIA: Time for Europe to regain its Rx innovation

Nov. 8, 2022
By Mari Serebrov
Europe is losing its innovative edge in biopharma, especially when it comes to advanced therapy medicinal products, including tissue, gene and cell therapies used to prevent, treat and cure rare conditions and some cancers.
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Cholesterol plaque in artery

Innovent bolsters case for hypercholesterolemia MAb with phase III results

Nov. 8, 2022
By David Ho
Innovent Biologics Inc. said that, compared to a placebo, both doses of its anti-PCSK-9 monoclonal antibody tafolecimab tested in a phase III trial “yielded significant and durable reductions” in low-density lipoprotein cholesterol levels and showed a favorable safety profile in Chinese patients with non-familial hypercholesterolemia.
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Kidneys

Telix’s imaging agent meets primary, secondary endpoints in phase III kidney cancer trial

Nov. 8, 2022
By Tamra Sami
Radiopharmaceutical company Telix Pharmaceuticals Ltd’s TLX250-CDx (Zirconium (89Zr) TX250) met both primary and secondary endpoints in the phase III Zircon study in clear cell renal cell carcinoma, according to top-line data.
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American Society of Nephrology

Certa Therapeutics’ FT-011 delivers breakthrough results in inflammatory, fibrotic diseases

Nov. 8, 2022
By Tamra Sami
New research presented by the University of Michigan revealed groundbreaking results for Certa Therapeutics Pty Ltd.’s lead candidate, FT-011, for serious inflammatory and fibrotic diseases.
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Arga Medtech

Argá initiates trial to test CSE ablation system for treating atrial fibrillation

Nov. 7, 2022
By David Godkin
Argá Medtech SA said patients in the first stage of enrollment for a first-in-human clinical trial have been safely and effectively treated with an ablation system for treating atrial fibrillation (AF). The Coherent Sine Burst Electroporation (CSE) system uses a pulsed field ablation (PFA) sine waveform and single, configurable (circular, linear, and focal) ablation catheter to better treat patients suffering from AF.
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Illustration of red blood cells traveling in the arteries
2022 American Heart Association Scientific Sessions

No improvement in all-cause death seen in ISCHEMIA-EXTEND trial of PCI

Nov. 7, 2022
By Mark McCarty
The debate over medical management versus percutaneous coronary intervention (PCI) for patients with chronic coronary artery disease took a new twist thanks to data that PCI plus medical management was better than medical management alone for cardiovascular mortality.
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Telix’s imaging agent meets primary, secondary endpoints in phase III kidney cancer trial

Nov. 7, 2022
By Tamra Sami
Radiopharmaceutical company Telix Pharmaceuticals Ltd’s TLX250-CDx (Zirconium (89Zr) TX250) met both primary and secondary endpoints in the phase III Zircon study in clear cell renal cell carcinoma, according to top-line data.
Read More
Heart, DNA and ECG

Caution continues at US FDA as Verve’s gene editing therapy hit by clinical hold

Nov. 7, 2022
By Jennifer Boggs
Verve Therapeutics Inc.’s heart disease candidate, VERVE-101, is the latest gene editing-based therapy to hit a snag at the FDA, which issued a clinical hold, delaying the start of phase I testing in the U.S. News of the hold, which followed preclinical presentations over the weekend at the American Heart Association 2022 meeting, sent shares of Verve (NASDAQ:VERV) falling 30.5% to close Nov. 7 at $21.75.
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