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BioWorld - Monday, September 25, 2023
Home » Topics » Conferences

Conferences
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Macrophage releasing cytokines as a part of the body's immune response.
Cancer

TLR7-selective agonist shows potent cytokine induction in vitro and in vivo

Aug. 31, 2023
No Comments
Researchers from Bristol Myers Squibb Co. presented the discovery of novel Toll-like receptor 7 (TLR7) agonists as potential new anticancer agents.
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Cardiovascular

Neuronal, blood vessel miscommunication affects aging heart: study

Aug. 31, 2023
By Anette Breindl
No Comments
Throughout the body, the vasculature and the nervous system are fellow travelers. Renaissance physician and anatomist Andreas Vesalius described their proximity on the macroanatomical level in the 16th century, and modern microscopic techniques have shown that it extends into the micrometer range – where there is a blood vessel, there is often a nerve nearby, and vice versa.
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DNA double helix with sand hour glass

Biomarker brainteaser: Aging? Or just changing?

Aug. 30, 2023
By Anette Breindl
No Comments
“Change is the only constant” is an ageless truth. In the search for age-related biomarkers, it is also a prosaic confounding factor.

Age-related biomarkers will be critical for the development of antiaging therapeutics. “Nobody is planning to do a life span study in humans,” Eric Verdin told the audience at the 10th Conference on Aging Research and Drug Development in Copenhagen on Monday. “Hence the need for … surrogate markers.”
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Test tubes, dropper
Respiratory

GDC-6599, a new TRPA1 antagonist with a promising preclinical PK and toxicity profile

Aug. 30, 2023
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Researchers from Genentech Inc. presented preclinical data for the novel transient receptor potential ankyrin 1 (TRPA1) antagonist GDC-6599, currently in phase II development for respiratory indications.
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Vascular system
Cardiovascular

Eli Lilly presents the preclinical profile of LY-3473329

Aug. 30, 2023
No Comments
Human lipoprotein(a) (Lp(a)) is a lipoprotein complex composed of a low-density lipoprotein (LDL) particle and a large highly polymorphic glycoprotein named apolipoprotein (a) (apo(a)). There is evidence that Lp(a) is linked to cardiovascular disorder risk.
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Colorful illustration of the heart
Endocrine/Metabolic

AT-02, a humanized IgG1-peptide fusion reagent that potently binds cardiac amyloid

Aug. 30, 2023
No Comments
At the recent ESC Congress, researchers from University of Tennessee and Attralus Inc. presented preclinical data on the novel pan-amyloid-binding peptide fusion immunoglobulin AT-02, which is being developed for the treatment of amyloidosis.
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Hematologic

Epigenetic modifier modulator CS-014 shows good clot prevention profile in vivo

Aug. 30, 2023
No Comments
Under pathologic conditions such as vascular injury or atherosclerosis, the hyperactivation of platelets may lead to occlusive thrombus formation, myocardial infarction or stroke. Although there are several targets for clot prevention validated clinically, these strategies may present bleeding risk as a limitation. Researchers from the University of Michigan have reported on CS-014, a histone deacetylase (HDAC) inhibitor aimed to reduce clot formation without risk of bleeding.
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DNA double helix with sand hour glass
Biomarkers

Biomarker brainteaser: Aging? Or just changing?

Aug. 30, 2023
By Anette Breindl
No Comments
“Change is the only constant” is an ageless truth. In the search for age-related biomarkers, it is also a prosaic confounding factor. Age-related biomarkers will be critical for the development of antiaging therapeutics. “Nobody is planning to do a life span study in humans,” Eric Verdin told the audience at the 10th Conference on Aging Research and Drug Development in Copenhagen on Monday. “Hence the need for … surrogate markers.” And “we are not there … we are actually quite far from there.”
Read More
3D illustration of Cryptosporidium oocysts releasing sporozoites
Infection

Novartis discloses a novel soft-drug strategy for cryptosporidiosis

Aug. 29, 2023
No Comments
Cryptosporidiosis is a parasitic infection caused by Cryptosporidium where infected individuals develop profuse watery diarrhea and enteric symptoms such as abdominal pain. In immunocompromised or malnourished children, the infection may become chronic and lead to significant morbidity and mortality rates.
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Colorized transmission electron micrograph of SARS-CoV-2.
Infection

Next-generation oral SARS-CoV-2 Mpro inhibitor disclosed

Aug. 29, 2023
No Comments
Viral proteases are well-established therapeutic targets in HIV and hepatitis C virus infections. Following the recent COVID-19 pandemic, one of the strategies in place is SARS-CoV-2 main protease (Mpro) inhibition, given the crucial role of SARS-CoV-2 Mpro in the replication of the virus.
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