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BioWorld - Saturday, July 19, 2025
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

A genipin derivative that may combat triple-negative breast cancer by stimulating ferroptosis

July 3, 2025
No Comments
Researchers at China Pharmaceutical University and collaborators have developed a promising drug lead against triple-negative breast cancer.
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Microscopic image of clear cell carcinoma, the most common type of renal cell carcinoma.
Cancer

[68Ga]NXK-44 radiotracer arises as a promising agent for RCC

July 3, 2025
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Chinese researchers from Huazhong University of Science and Technology have developed a novel carbonic anhydrase IX (CAIX)-targeting radiotracer, [68Ga]NXK-44, for the imaging of hypoxic tumors and renal cell carcinoma (RCC).
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Ovarian cancer illustration
Cancer

Preclinical results of first-in-class PTK7-targeted radionuclide therapy in ovarian cancer

July 3, 2025
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Researchers from the University of Oslo and Oncoinvent ASA present a new PTK7-targeted α therapy using a lead-212 (212Pb)-labeled antibody, potentially offering a novel approach for treating PTK7-expressing malignancies, and its assessment in a preclinical study.
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Cancer research illustration
Immuno-oncology

Boehringer Ingelheim selects new oncology drug candidate from Oxford Biotherapeutics collaboration

July 3, 2025
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Boehringer Ingelheim Pharma GmbH & Co KG has selected a third oncology drug candidate to advance into IND-enabling studies under its ongoing collaboration with Oxford Biotherapeutics Ltd.
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AI-generated illustration of CAR T cells
Immuno-oncology

Researchers arm CAR T cells to fight solid tumors

July 3, 2025
By Tamra Sami
No Comments
Aussie researchers have used CRISPR gene editing tools to “armor” chimeric antigen receptor (CAR) T cells to activate additional cancer-fighting proteins at the tumor site, enabling them to target cancer cells in solid tumors.
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Multiple myeloma illustration

Regeneron wins FDA nod for BCMA bispecific Lynozyfic

July 2, 2025
By Jennifer Boggs
No Comments

It may be a year later than originally planned, but Regeneron Pharmaceuticals Inc. is set to commercialize Lynozyfic (linvoseltamab) in the U.S. following FDA approval for use in adults with relapsed and refractory multiple myeloma. A bispecific antibody targeting B-cell maturation antigen (BCMA) and CD3, Lynozyfic was cleared under the accelerated approval pathway, with continued approval contingent upon a confirmatory trial.


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Market rebound illustration
Index insights

Cancer index outperforms broader markets with 13% Q2 rebound

July 2, 2025
By Amanda Lanier
No Comments
The BioWorld Cancer Index reversed its early year losses, rebounding from a 4.74% decline at the end of the first quarter (Q1) to finish Q2 up 12.78%. The Dow Jones Industrial Average followed a similar pattern, dropping to -4.41% by the end of April before recovering to a 3.64% gain by Q2’s end. Meanwhile, the Nasdaq Biotechnology Index, down 5.37% at the end of May, narrowed its losses to close June down just 1.92%.
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Molecule illustration
Immune

Unnatural Products joins Argenx in a $1.5B macrocyclic deal

July 2, 2025
By Lee Landenberger
No Comments
Unnatural Products Inc. notched another collaboration by signing on with Argenx SE in a multitarget research collaboration. Unnatural Products, which is getting up-front, near-term payments and R&D funding, could end up with about $1.5 billion in milestones and options payments plus tiered royalties on net sales.
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Cancer

Pfizer discovers new KAT2A and KAT2B inhibitors

July 2, 2025
Pfizer Inc. has described acetyltransferase KAT2A and/or KAT2B inhibitors reported to be useful for the treatment of cancer.
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Cancer

Kestrel Therapeutics describes new GTPase KRAS inhibitors

July 2, 2025
Kestrel Therapeutics Inc. has identified GTPase KRAS inhibitors reported to be useful for the treatment of cancer.
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