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Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Endocrine/metabolic

PD-1-FABP5 axis regulates metabolism in obesity

Feb. 25, 2025
Resident immune cells, including type 2 innate lymphoid cells (ILC2s), play a key role in adipose tissue homeostasis. Researchers from Sungkyunkwan University and affiliated organizations evaluated the impact of ILC2s on systemic metabolic regulation in obesity.
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Endocrine/metabolic

Nerio Therapeutics divulges new PTPN1 and PTPN2 degradation inducers

Feb. 25, 2025
Nerio Therapeutics Inc. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety coupled to a tyrosine-protein phosphatase non-receptor type 1 (PTPN1; PTP-1B) and/or tyrosine-protein phosphatase non-receptor type 2 (PTPN2; TCPTP) targeting moiety through a linker reported to be useful for the treatment of cancer, type 2 diabetes, obesity and metabolic diseases.
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Nasal spray
Drug design, drug delivery & technologies

Intranasal bacterium for targeted brain delivery

Feb. 24, 2025
In a recent publication in Cell, researchers from the National University of Singapore and collaborators have proposed using commensal bacteria in the nasal cavity as a delivery vector for precision therapy targeting the OE and brain.
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3D rendered medical illustration of the pituitary gland
Endocrine/metabolic

Study links higher USP11 levels to increased Cushing’s disease risk in women

Feb. 24, 2025
A recent study published in Acta Neuropathologica Communications sheds light on the gender disparity in the incidence of ACTH-secreting pituitary neuroendocrine tumors (PitNETs), which occur more frequently in females than in males.
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Oral medication

Mirum’s Ctexli wins FDA nod in cerebrotendinous xanthomatosis

Feb. 21, 2025
By Jennifer Boggs
Though it’s been used off-label for more than three decades to treat cerebrotendinous xanthomatosis, Mirum Pharmaceuticals Inc.’s chenodiol gained an official U.S. FDA nod Feb. 21 as the first drug approved specifically for treating the rare autosomal recessive lipid storage disease.
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Endocrine/metabolic

CSPC Zhongnuo Pharmaceutical discovers new GLP-1R agonists

Feb. 21, 2025
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co. Ltd. has described glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of diabetes, obesity, Alzheimer’s disease, overweight and nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH).
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Endocrine/metabolic

Hansoh describes new GLP-1R agonists

Feb. 21, 2025
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have identified glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of diabetes, obesity and nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH).
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Endocrine/metabolic

MBX Biosciences unveils new, long-acting antiobesity asset

Feb. 21, 2025
Researchers from MBX Biosciences Inc. presented preclinical data on MBX-4291, a prodrug developed as a long-acting GLP-1/GIP co-agonist through MBX’s proprietary Precision Endocrine Peptide (PEP) platform.
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Copper-colored DNA on blue background

Copper wired: Monopar to electrify Wilson disease?

Feb. 19, 2025
By Randy Osborne
Research seems to be gaining ground in Wilson disease, a rare inherited condition that causes copper levels to accumulate in the liver, brain and eyes. Most people are diagnosed as children or around middle age, but the age spectrum can be wide. Monopar Therapeutics Inc. has drawn Wall Street’s attention in the space.
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Endocrine/metabolic

Septerna to change candidate for hypoparathyroidism

Feb. 19, 2025
Septerna Inc. has announced its decision to discontinue a healthy volunteer phase I trial of SEP-786, an oral small-molecule agonist of the parathyroid hormone 1 receptor being developed for the treatment of hypoparathyroidism.
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