In the largest study to date for Crohn's disease, researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard identified rare variants of 10 genes associated with this pathology. The researchers sequenced the exomes of 110,000 people, 30,000 patients with Crohn's and 80,000 without this condition, with the participation of a hundred international scientific institutions.
Glucagon-like peptide 1 (GLP-1) signaling to intraepithelial lymphocyte (IEL) cells in the gut, where most GLP-1 is made, was important for inflammation in the gut itself, but less so for systemic inflammation.
PharminoGen has presented prazole-carboxamide derivatives acting as cannabinoid CB1 receptor antagonists reported to be useful for the treatment of non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, dyslipidemia and diabetes.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal tract that often causes the development of colorectal cancer (CRC).
Viking Therapeutics has divulged dual agonists of GLP-1 and glucose-dependent insulinotropic receptor (GDIR) reported to be useful for the treatment of nonalcoholic fatty liver disease (NAFLD).
Sunshine Lake Pharma has synthesized amide pyrrole compounds reported to be useful for the treatment of liver cancer, cirrhosis and hepatitis B virus (HBV) infection.
Apeloa Pharmaceutical and Hangzhou Apeloa Medicine Research Institute have described new N-(benzoyl)-phenylalanine compounds acting as integrin alpha4beta7 (LPAM-1) antagonists reported to be useful for the treatment of inflammatory bowel disease.
Secretion of gastric acid is tightly controlled by the neuroendocrine system of the stomach, formed by an interconnected network of nerves and different hormone-producing cell types, particularly G cells that release the hormone gastrin.
GentiBio announced that it has entered into a collaboration with Bristol Myers Squibb to develop new engineered regulatory T cell (Treg) therapies to re-establish immune tolerance and repair tissue in patients living with inflammatory bowel diseases (IBD).
Prometheus Biosciences Inc.’s stock-boosting news July 26 put more investor eyes on inflammatory bowel disease (IBD), where the company during its R&D Day revealed the target of PRA-052, the clinical candidate that emerged from the program known as PR-600. PRA-052 takes aim at the CD30 ligand, which acts as a co-stimulatory molecule to drive T-cell proliferation and differentiation.
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