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BioWorld - Sunday, March 1, 2026
Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
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Liver illustration
Gastrointestinal

Hydrazide-based HDAC1/2/3 inhibitor decreases liver fibrosis in mouse models

June 19, 2024
The search for an effective therapy for liver fibrosis continues. A recent study by researchers at Medical University of South Carolina and collaborators explored the potential of a new compound, LP-340, as a treatment for liver fibrosis.
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Illustration of intestines with inflammation

Futuregen joins Abbvie in $1.7B inflammatory bowel disease deal

June 18, 2024
By Lee Landenberger
Through a global rights agreement with Futuregen Biopharmaceutical Co. Ltd., Abbvie Inc. continues to build its immunology portfolio to help offset losses from Humira as biosimilars tighten their grip on the mega-blockbuster.
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Madrigal is the NASH/MASH master … of the moment

June 18, 2024
By Lee Landenberger
For the time being, Madrigal Pharmaceuticals Inc.’s Rezdiffra (resmetirom) stands alone as the only U.S. FDA approved treatment for treating nonalcoholic steatohepatitis (NASH). But new and positive data from multiple companies show Madrigal may soon have company.
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Microscope with beakers and flasks
Gastrointestinal

Enveda Biosciences raises financing to advance anti-inflammatory programs

June 17, 2024
Enveda Biosciences (Enveda Therapeutics Inc.) has announced a new series B2 financing round of $55 million. The drug discovery and development company uses artificial intelligence (AI)-powered technologies to translate nature into new medicines.
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Illustration of intestines with inflammation

Futuregen joins Abbvie in $1.7B inflammatory bowel disease deal

June 14, 2024
By Lee Landenberger
Through a global rights agreement with Futuregen Biopharmaceutical Co. Ltd., Abbvie Inc. continues to build its immunology portfolio to help offset losses from Humira as biosimilars tighten their grip on the mega-blockbuster.
Read More
Gastrointestinal

Abbvie licenses Futuregen’s next-generation TL1A antibody for inflammatory bowel disease

June 14, 2024
Abbvie Inc. and Futuregen Biopharmaceutical (Beijing) Co. Ltd. have signed a license agreement to develop FG-M701, a next-generation TL1A antibody for the treatment of inflammatory bowel disease.
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Nexsphere

Drug-device developer Next Biomedical files for Kosdaq IPO

June 12, 2024
By Marian (YoonJee) Chu
Incheon, South Korea-based Next Biomedical plans to offer one million shares on the Korea Exchange at a price band of ₩24,000 (US$17.42) to ₩29,000 per share. The IPO is scheduled for August 2024 and expected to raise ₩24 billion to ₩29 billion.
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Gastrointestinal

Roche presents HIF-2α inhibitors for inflammatory bowel disease

June 12, 2024
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have described hypoxia inducible factor-2α (HIF-2α; EPAS1) inhibitors reported to be useful for treatment of ulcerative colitis and Crohn’s disease.
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Ipsen wins FDA nod for Iqirvo in primary biliary cholangitis

June 11, 2024
By Jennifer Boggs
Ipsen SA picked up U.S. FDA accelerated approval for its Genfit SA-licensed elafibranor, making it the first new drug in eight years for treating primary biliary cholangitis, though a potential competitor lurks just around the corner.
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AI-generated illustration of enzyme activity
Endocrine/metabolic

Syntis Bio advances oral enzyme replacement therapies toward IND filing

June 11, 2024
Syntis Bio Inc. has announced its launch, with a focus on advancing a pipeline of oral therapies engineered for optimization in the small intestine and a portfolio of enzyme replacement therapies to treat orphan metabolic and broad digestive disorders.
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