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Home » Topics » Disease categories and therapies » Immune

Immune
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 18, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos.
Read More
Deal illustration

Astrazeneca makes $5.3B drug R&D pact with CSPC

June 17, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. announced June 13 that it struck a potential $5.33 billion deal with Astrazeneca plc to develop novel preclinical small-molecule candidates using CSPC’s AI-driven drug development platform.
Read More
Multiple myeloma illustration

Cullinan deals $712M to test Genrix bispecific TCE in autoimmune

June 17, 2025
By Marian (YoonJee) Chu
No Comments
Cullinan Therapeutics Inc. swept up ex-China rights to a multiple myeloma (MM)-targeting BCMAxCD3 bispecific T-cell engager (TCE) velinotamig from Chongqing Genrix Biopharmaceutical Co. Ltd. via a potential $712 million deal June 4. The plan is to repurpose the cancer drug to autoimmune disease.
Read More
Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
Read More
Fibroblast illustration
Immune

AM-1476 inhibits 5-HT2B receptor with preclinical antifibrotic effects

June 17, 2025
No Comments
Systemic sclerosis (SSc) is a particularly severe form of fibrotic disease that affects multiple organs. SSc is the most deadly autoimmune rheumatic disease.
Read More
Musculoskeletal

New tracer has diagnostic utility for rheumatoid arthritis

June 17, 2025
No Comments
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints. PET/CT imaging is a useful tool for early disease assessment and monitoring treatment efficacy.
Read More
Lab glassware and antibodies art concept
Immune

Glucocorticoid ADC targets immune cells in disease models

June 17, 2025
No Comments
Researchers from Lifordi Immunotherapeutics Inc. have developed a novel antibody-drug conjugate (ADC) called LFD-200 that aims to selectively deliver a potent glucocorticoid (GC) payload directly to immune cells. This strategy may potentially offer a new way to treat autoimmune and inflammatory conditions while minimizing systemic toxicity.
Read More
Deal illustration

Astrazeneca makes $5.3B drug R&D pact with CSPC

June 16, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. announced June 13 that it struck a potential $5.33 billion deal with Astrazeneca plc to develop novel preclinical small-molecule candidates using CSPC’s AI-driven drug development platform.
Read More
Immune

Dana-Farber Cancer Institute patents new SHP-1 agonists

June 16, 2025
Dana-Farber Cancer Institute Inc. has synthesized tyrosine-protein phosphatase non-receptor type 6 (PTPN6; PTP-1C; SH-PTP1) activators reported to be useful for the treatment of autoimmune disease and cancer.
Read More
Illustration of antibodies attacking nerve cells
Immune

A carborane agonist of estrogen receptor β against systemic lupus erythematosus

June 16, 2025
No Comments
Systemic lupus erythematosus is a chronic autoimmune disease in which immune cells invade various organs and unleash harmful inflammatory responses. Estrogen may contribute to the condition, which would explain why it affects women over men in a 9:1 ratio.
Read More
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