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Home » Topics » Disease categories and therapies » Immune

Immune
Immune RSS Feed RSS

CAR T cells attacking cancer cell
Immuno-oncology

In vivo generation could expand CAR T cells’ reach

June 23, 2025
By Xavier Bofill Bruna
No Comments
Chimeric antigen receptor (CAR) T-cell therapy has been a game changer in the treatment of B-cell malignancies, although their manufacturing process is complex and needs lymphodepletion, thus limiting their use. Researchers from Capstan Therapeutics Inc. have recently published data regarding an in vivo engineering approach to generate CAR T cells using targeted lipid nanoparticles (LNPs) for mRNA delivery to specific T-cell populations for the treatment of cancer and B-cell-mediated autoimmune diseases.
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AI-generated illustration of DNA double helix

Drug Farm harvests new immunomodulators with AI-gene editing tech

June 20, 2025
By Marian (YoonJee) Chu
No Comments
Shanghai Yao Yuan Biotechnology Ltd., also known as Drug Farm, is advancing a portfolio of immune-modulating therapies for various indications including hepatitis B virus, hepatocellular cancer and a relatively new rare genetic disease called ROSAH, an acronym for retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache.
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Immune

Bovine adenoviral vector-based bivalent vaccine protects mice and ferrets from influenza A and B

June 20, 2025
No Comments
Researchers from Purdue University and the U.S. Centers for Disease Control and Prevention have recently developed a novel influenza vaccine candidate that uses a bovine adenoviral (BAd) vector to deliver nucleoprotein (NP) antigens from both influenza A and B viruses, along with an autophagy-inducing peptide (C5) to enhance cellular immune responses, particularly T-cell responses.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 18, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos.
Read More
Deal illustration

Astrazeneca makes $5.3B drug R&D pact with CSPC

June 17, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. announced June 13 that it struck a potential $5.33 billion deal with Astrazeneca plc to develop novel preclinical small-molecule candidates using CSPC’s AI-driven drug development platform.
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Multiple myeloma illustration

Cullinan deals $712M to test Genrix bispecific TCE in autoimmune

June 17, 2025
By Marian (YoonJee) Chu
No Comments
Cullinan Therapeutics Inc. swept up ex-China rights to a multiple myeloma (MM)-targeting BCMAxCD3 bispecific T-cell engager (TCE) velinotamig from Chongqing Genrix Biopharmaceutical Co. Ltd. via a potential $712 million deal June 4. The plan is to repurpose the cancer drug to autoimmune disease.
Read More
Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
Read More
Fibroblast illustration
Immune

AM-1476 inhibits 5-HT2B receptor with preclinical antifibrotic effects

June 17, 2025
No Comments
Systemic sclerosis (SSc) is a particularly severe form of fibrotic disease that affects multiple organs. SSc is the most deadly autoimmune rheumatic disease.
Read More
Musculoskeletal

New tracer has diagnostic utility for rheumatoid arthritis

June 17, 2025
No Comments
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints. PET/CT imaging is a useful tool for early disease assessment and monitoring treatment efficacy.
Read More
Lab glassware and antibodies art concept
Immune

Glucocorticoid ADC targets immune cells in disease models

June 17, 2025
No Comments
Researchers from Lifordi Immunotherapeutics Inc. have developed a novel antibody-drug conjugate (ADC) called LFD-200 that aims to selectively deliver a potent glucocorticoid (GC) payload directly to immune cells. This strategy may potentially offer a new way to treat autoimmune and inflammatory conditions while minimizing systemic toxicity.
Read More
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