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BioWorld - Sunday, March 26, 2023
Home » Topics » Disease categories and therapies » Immune

Immune
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Immune

Thymmune Therapeutics raises funding to advance thymic cell therapies

March 2, 2023
No Comments
Thymmune Therapeutics Inc. has secured US$7 million in seed financing to support its work in developing scalable thymic cell therapies to restore immune function in aging and disease.
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Biomarkers

RELMβ as novel biomarker and pathogenic player in children with food allergy

March 2, 2023
No Comments
Resistin-like molecule beta (RELMβ) is a gut-derived cytokine involved in both allergic responses and protection from pathogens, and it has been previously found to be dysregulated in mouse models of food allergy (FA). Researchers from Boston Children’s Hospital aimed assess the potential of RELMβ as a novel biomarker in children with FA.
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Mast cell releasing histamine during allergic response
Immune

MOD-000001, a novel orally available KIT inhibitor with efficacy in models of allergic disease

March 1, 2023
No Comments
It has been demonstrated that stem cell factor (SCF) and its receptor KIT play key roles in the differentiation, proliferation, survival, migration and activation of mast cells, which in turn play a central role in the development of IgE-mediated allergic diseases, including allergic urticaria and food allergy.
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Immune

BTK inhibition ameliorates clinical reactivity to peanuts in allergic patients

Feb. 28, 2023
No Comments
It is known that Bruton tyrosine kinase (BTK) is an essential enzyme for the FcεRI signaling pathway and is thought to be a target to prevent IgE-mediated allergic reactions. Researchers have hypothesized that the BTK inhibitor acalabrutinib may prevent reactivity to peanuts in patients with peanut allergy.
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Table with foods that commonly cause allergic reactions
Immune

Immunomodulatory peptide IRL-201104 shows long-lasting efficacy in murine model of food allergy

Feb. 28, 2023
No Comments
Researchers from Revolo Biotherapeutics Ltd. have presented preclinical data for IRL-201104, a clinical-stage immunomodulatory peptide that has previously demonstrated a long-lasting effect in different preclinical models of allergic inflammation. In the new studies, the candidate was assessed in models of food allergy.
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Mast cell
Inflammatory

AK-006 anti-Siglec-6 MAb suppresses mast cell activity in several models

Feb. 28, 2023
No Comments
Mast cells (MCs) are one of the key drivers of acute and chronic inflammation and can be activated...
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Man scratching arm
Biomarkers

SORBS1 gene polymorphism impacts atopic dermatitis risk through milk exposure, study finds

Feb. 27, 2023
No Comments
Environmental factors, such as those from food allergens, can modulate IgE-driven hypersensitivity related to the genetics of allergy. Researchers from the Korea National Institute of Health aimed to investigate the impact of polymorphisms in the SORBS1 gene in relation to atopic dermatitis based on milk exposure.
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Mast cell releasing histamine during allergic response
Immune

EP-262 inhibits agonist-induced mast cell degranulation and vascular permeability in vivo

Feb. 27, 2023
No Comments
At the ongoing AAAAI meeting in San Antonio, researchers from Escient Pharmaceuticals Inc. presented preclinical data for the Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist EP-262, being evaluated as a novel therapeutic approach for mast cell-mediated diseases. In vitro, EP-262 acted as a potent and highly selective antagonist of MRGPRX2, which inhibited MRGPRX2 activation induced by a wide variety of agonists.
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Stock chart, red down arrow

Hopes pinned to AD for Nektar’s rezpeg as partner Lilly drops lupus bid on phase II data

Feb. 24, 2023
By Jennifer Boggs
No Comments
Nektar Therapeutics Inc. President and CEO Howard Robin didn’t mince words during a call with investors after market close Feb. 23 to disclose top-line data from a phase II study testing rezpegaldesleukin (rezpeg) in systemic lupus erythematosus, which fell short of partner Eli Lilly and Co.’s criteria for advancing to phase III and raised uncertainty as to how the big pharma might proceed in other indications such as atopic dermatitis (AD).
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Infection

Development of recombinant protein vaccines formulated with R-DOTAP

Feb. 24, 2023
No Comments
Researchers from PDS Biotechnology Corp. and affiliated organizations have detailed the development and preclinical evaluation of recombinant protein vaccines formulated with enantio-specific cationic lipid R-DOTAP.
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