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BioWorld - Monday, February 6, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
Infection RSS Feed RSS

Valneva posts positive chikungunya vaccine data

Dec. 5, 2022
By Lee Landenberger
No Comments
Twelve months after a single shot of Valneva SE’s chikungunya vaccine, positive antibody persistence was found, threatening a deadly disease that has long resisted treatment. The new data are derived from a study of 363 healthy adult participants that followed them from month 6 after vaccination to month 12. Nearly all, 99%, kept their neutralizing antibody titers for 12 months beyond the seroresponse threshold of 150, which hit the primary endpoint and the antibody level agreed with regulators as endpoint under the accelerated approval pathway.
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Infection

George Washington University discovers new antimicrobial agents for malaria and tuberculosis

Dec. 2, 2022
No Comments
George Washington University has described N-ACYL fosmidomycin prodrug analogues acting as 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr; IspC) (Mycobacterium tuberculosis) and Dxr (Plasmodium falciparum) inhibitors reported to be useful for the treatment of malaria and tuberculosis.
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Hepatitis B virus
Infection

Bluejay set to advance BJT-778 for chronic hepatitis B and chronic hepatitis D

Dec. 2, 2022
No Comments
Bluejay Therapeutics Inc. has received approval from the New Zealand Medicines and Medical...
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Syringe and ampoules

Researchers establish proof of concept for germline-targeting HIV vaccine

Dec. 1, 2022
By Michael Fitzhugh
No Comments
A diverse group of government and academic researchers, marking World AIDS Day 2022, have published details of an investigational vaccine they said safely induced broadly neutralizing antibody-precursors against HIV in nearly all participants in a small phase I trial.
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Clostridium difficile bacteria

Ferring’s fecal microbiota approval is a first for the FDA

Dec. 1, 2022
By Lee Landenberger
No Comments
The U.S. FDA has approved its first fecal microbiota treatment. Rebyota (fecal microbiota, live-jslm), from privately held Ferring Pharmaceuticals Inc., is now approved to prevent recurring Clostridioides difficile infection (CDI) in adults. The Nov. 30 approval came about two months after the FDA’s Vaccines and Related Biological Products Advisory Committee voted 13-4 to support the microbiome therapy’s effectiveness in reducing recurrent CDI in adults after antibiotic treatment for recurrent CDI.
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Infection

Quantbiores patents SARS-CoV-2 spike glycoprotein/ACE2 interaction inhibitors

Dec. 1, 2022
No Comments
Quantbiores A/S has discovered peptides acting as spike glycoprotein (S) (SARS-CoV-2)/ACE2 interaction inhibitors reported to be useful for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19).
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Infection

Texas A&M University System divulges new SARS-CoV-2 3CLpro and CYP3A4 inhibitors

Nov. 30, 2022
No Comments
Texas A&M University System has discovered 3C-like proteinase (3CLpro) (SARS-CoV-2; COVID-19 virus) and cytochrome P450 3A4 (CYP3A4) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection.
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Three alpacas
Infection

Biondvax reports in vivo data with inhaled NanoAb COVID-19 therapy

Nov. 30, 2022
No Comments
Biondvax Pharmaceuticals Ltd. has reported statistically significant efficacy results from an in vivo proof-of-concept study of its innovative inhaled nanosized antibody (NanoAb) COVID-19 therapy.
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Infection

Medshine Discovery divulges new HBV antiviral compounds

Nov. 29, 2022
No Comments
Medshine Discovery Inc. has disclosed compounds reported to be useful for the treatment of chronic hepatitis B.
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Infection

Osaka University presents new murine model of chronic hepatitis B

Nov. 22, 2022
No Comments
Animal models recapitulating the immune features of chronic hepatitis B (CHB) are very limited. An Osaka University research team has developed a novel murine model of CHB and tested the efficacy and immunomodulating effects of interferon-α (IFN-α) therapy.
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