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BioWorld - Monday, February 6, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
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3D renderings of RSV
Infection

Antibody effector functions predict protection against RSV re-infection

Dec. 13, 2022
By Helen Albert
No Comments
Both neutralizing antibodies and antibody effector functions are needed for protection against re-infection with respiratory syncytial virus (RSV), which may explain why it has been challenging to design an effective vaccine against the virus. As reported in the Dec. 12, 2022, issue of Cell, researchers carried out a human challenge study where volunteers were given a candidate vaccine for RSV, Ad26, or placebo.
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Infection

Ligand Pharmaceuticals patent details antiviral prodrugs

Dec. 12, 2022
No Comments
Ligand Pharmaceuticals Inc. has divulged prodrugs of clevudine and telbivudine reported to be useful for the treatment of hepatitis, diabetes, malaria, obesity, atherosclerosis, cancer, viral infections and cancer.
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Infection

CSPC's small-molecule 3CLpro inhibitor SYH-2055 cleared for clinical trials in China

Dec. 9, 2022
No Comments
CSPC Pharmaceutical Group Ltd. has obtained clearance from China's National Medical Products Administration (NMPA) to conduct clinical trials in China with SYH-2055, an oral small-molecule 3C-like protease (3CLpro) inhibitor against SARS-CoV-2.
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SARS-CoV-2-hero-BWS.png
Infection

Targeting bile acid receptor could help prevent SARS-CoV-2 infection

Dec. 9, 2022
By Nuala Moran
No Comments
New research has identified a novel receptor that interacts with the angiotensin-converting enzyme 2 (ACE2) by which the SARS-CoV-2 enters host cells, and shown it can be inhibited with marketed drugs, reducing expression of ACE2 and blocking viral entry.
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Antibiotic resistant bacteria inside a biofilm,
Infection

Researchers identify new class of antibiotic resistance mechanism

Dec. 8, 2022
By Mar de Miguel
No Comments
When a drug prevents bacteria from synthesizing their own folate, an essential compound for their survival, they take it directly from the host. This antibiotic resistance mechanism had not been detected until now because bacteria behave differently in the laboratory than they do in vivo during an infection.
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Eiger’s D-LIVR study delivers the composite endpoint but stock stumbles

Dec. 8, 2022
By Lee Landenberger
No Comments
Top-line primary data from week 48 of Eiger Biopharmaceuticals Inc.'s phase III D-LIVR study of lonafarnib, a prenylation inhibitor for treating chronic hepatitis delta virus, also known as hepatitis D, hit statistical significance vs. a placebo in the composite primary endpoint.
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Respiratory infection
Infection

Tetra reports AI study results of ARDS-003 in combination with favipiravir

Dec. 7, 2022
No Comments
Tetra Bio-Pharma Inc. has reported results from a study of ARDS-003 (onternabez) combined with favipiravir against acute respiratory distress syndrome (ARDS), sepsis and COVID-19 through PREPAiRE, an artificial intelligence (AI)-powered platform which integrates target identification, validation, lead discovery optimization, drug synthesis and preclinical testing.
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Microscope and coronavirus illustration
Infection

Pfizer and Clear Creek collaborate on SARS-CoV-2 PLpro inhibitors for COVID-19

Dec. 7, 2022
No Comments
Pfizer Inc. and Clear Creek Bio Inc. have entered into a research collaboration and exclusive license agreement to advance the discovery and development of potential inhibitors of the SARS-CoV-2 papain-like protease (PLpro) for the oral treatment of COVID-19.
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Gloved hand holding COVID-19 vaccine vial, syringe
Infection

CEPI and VBI expand scope of partnership to target coronavirus threats

Dec. 7, 2022
No Comments
The Coalition for Epidemic Preparedness Innovations (CEPI) has expanded its partnership with VBI Vaccines Inc. to advance the development of multivalent coronavirus vaccines that could be deployed against COVID-19 and possible future coronaviruses with pandemic potential, referred to as coronavirus X.
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Infection

Researchers identify new class of antibiotic resistance mechanism

Dec. 7, 2022
By Mar de Miguel
No Comments
When a drug prevents bacteria from synthesizing their own folate, an essential compound for their survival, they take it directly from the host. This antibiotic resistance mechanism had not been detected until now because bacteria behave differently in the laboratory than they do in vivo during an infection.
Read More
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