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BioWorld - Monday, February 6, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
Infection RSS Feed RSS

Moderna’s RSV vaccine races to catch up with Pfizer and GSK

Jan. 18, 2023
By Lee Landenberger
No Comments
Now there are three. Moderna Inc. has posted strong phase III study data on its mRNA respiratory syncytial virus (RSV) vaccine, keeping pace with Pfizer Inc. and GSK plc’s candidates, which have May PDUFA dates. Moderna’s top-line results of the ConquerRSV pivotal efficacy study of mRNA-1345 show the vaccine hit its primary efficacy endpoints of 83.7% against RSV-associated lower respiratory tract disease in older adults.
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Newco news

After fecal microbiota approval, Biomebank to develop synthetic treatments for gut microbiota

Jan. 17, 2023
By Tamra Sami
No Comments
Following Therapeutic Goods Administration approval of its first-generation donor-derived microbiome-based therapy, Biomictra, for recurrent Clostridioides difficile infection, Australia’s Biomebank is scaling up to meet increasing global demand for fecal microbiota products and is developing a more scalable second-generation synthetic product.
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Infection

Debiopharm International presents new antibacterial compounds

Jan. 17, 2023
No Comments
Debiopharm International SA has identified enoyl-(acyl-carrier protein) reductase FabI (Acinetobacter baumannii) inhibitors reported to be useful for the treatment of bacterial infections and hospital-acquired pneumonia.
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Infection

Shanghai Qilu Pharmaceutical Research and Development Centre synthesizes new compounds for HBV infection

Jan. 17, 2023
No Comments
Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. has presented HBeAg (hepatitis B virus; HBV) and/or HBsAg (HBV) secretion inhibitors reported to be useful for the treatment of HBV infections.
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Colorized scanning electron micrograph of N. gonorrhoeae bacteria.
Infection

Intranasally administered gonococcal OMVs plus microsphere-encapsulated IL-12 show efficacy in vivo

Jan. 16, 2023
No Comments
Researchers from Therapyx Inc. and Intravacc BV assessed the potential of intranasal administration of a novel gonococcal vaccine candidate consisting of outer membrane vesicles (OMVs) and microsphere (ms)-encapsulated interleukin-12 (IL-12 ms). It was previously demonstrated that female mice can be immunized intravaginally with gonococcal OMVs plus IL-12 ms to induce anti-gonococcal antibodies and resistance to genital tract challenge with live Neisseria gonorrhoeae.
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Newco news

After fecal microbiota approval, Biomebank to develop synthetic treatments for gut microbiota

Jan. 13, 2023
By Tamra Sami
No Comments
Following Therapeutic Goods Administration approval of its first-generation donor-derived microbiome-based therapy, Biomictra, for recurrent Clostridioides difficile infection, Australia’s Biomebank is scaling up to meet increasing global demand for fecal microbiota products and is developing a more scalable second-generation synthetic product.
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Infection

Scripps Research divulges new 3CLpro inhibitors for SARS-CoV-2 infection

Jan. 13, 2023
No Comments
Scripps Research has synthesized 3C-Like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19).
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Streptococcus pneumoniae in lungs

Biopharmas at full strain to find broader PCVs; Vaxcyte, GSK, Merck in play

Jan. 12, 2023
By Randy Osborne
No Comments
Although strides have been made in the space, biopharma’s hunt for a wider net to cast in vaccines for pneumococcal disease has recruited the likes of Vaxcyte Inc., GSK plc and Merck & Co. Inc., each racing for a candidate with improved valence.
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Infection

Glaxosmithkline divulges new antimalarials

Jan. 12, 2023
No Comments
Glaxosmithkline Intellectual Property Ltd. has synthesized cytochrome bc1 complex (complex III) (Plasmodium falciparum) inhibitors reported to be useful for the treatment of malaria.
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Bacterial colonies in petri dishes
Infection

Discovery of novel multitargeting antibacterial agents

Jan. 12, 2023
No Comments
Scientists from Southwest University and...
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