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BioWorld - Saturday, June 14, 2025
Home » Topics » Disease categories and therapies » Infection

Infection
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3D illustration of phage infecting bacteria

MHRA offers clarity for bacteriophage development, licensing

June 9, 2025
By Nuala Moran
No Comments
The U.K. Medicines and Healthcare products Regulatory Agency (MHRA) has issued its first official guidance on how to develop bacteriophages as licensed medicinal products. This covers personalized phage therapies designed for specific patients – at present the only form in which they are available – but also is relevant to the development of off-the-shelf products for treating common infections.
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Vaxxas HD-MAP administration

Microneedles could solve vaccine distribution challenges

June 6, 2025
By Tamra Sami
Microneedle technology could help simplify vaccine delivery to better support global immunization efforts, and Australia is leading the way in this innovative technology.
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Infection

Gilead Sciences divulges new compounds to treat herpes virus infection

June 6, 2025
Gilead Sciences Inc. has synthesized indoline compounds acting as DNA helicase-primase complex (human herpes simplex virus) and viral replication inhibitors reported to be useful for the treatment of herpes virus infection.
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Structural model of dengue virus.
Immune

Immunoprecise Antibodies discovers highly conserved epitope across all four dengue virus serotypes

June 6, 2025
No Comments
Immunoprecise Antibodies Ltd. has discovered a highly conserved epitope across all four dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) using its proprietary Lensai platform powered by its Hyft technology.
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Pipet, test tubes, chemical structures
Infection

JMX-0312 protects hamsters from adenoviral lethal infection, study demonstrates

June 5, 2025
No Comments
Human adenovirus may cause severe infections in both immunosuppressed and immunocompetent individuals and there is no specific approved therapy for it to date. The incidence may be about 50%-60% in immunocompromised subjects, with mortality rates around 80% in patients with disseminated infections.
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US Fed Circuit rules in favor of Moderna in patent squabble

June 4, 2025
By Mari Serebrov
No Comments
Moderna Inc. once again emerged the winner in a court skirmish over claims that its COVID-19 vaccine infringed two Alnylam Pharmaceuticals Inc. patents. The U.S. Court of Appeals for the Federal Circuit issued a precedential opinion May 4, agreeing with a federal district court in Delaware that Moderna didn’t infringe the patents. For both courts, the decision was based on a single issue of claim construction.
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Infection

Czech scientists divulge new NSP14 inhibitors

June 2, 2025
Scientists at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences have synthesized nonstructural protein 14 (NSP14) (coronavirus) inhibitors reported to be useful for the treatment of coronavirus acute respiratory syndrome.
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Illustration of mast cell emitting granules
Drug design, drug delivery & technologies

Dual-action synthetic peptides could fight superbugs

June 2, 2025
By Mar de Miguel
No Comments
A peptide with a dual mechanism of action – it dissolves the bacterial membrane and activates the immune system – could be an effective weapon against microorganisms that have evolved ways to evade antibiotics, as superbugs do. Scientists at the University of Pennsylvania (UPenn) have designed stable synthetic peptides that activate mast cell receptors, which are cells involved in the innate and adaptive immune response. This dual approach eliminates bacteria and recruits neutrophils to finish the job.
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HHS terminating Moderna’s $590M grant for flu vaccines

May 29, 2025
By Jennifer Boggs
No Comments
The funding boost Moderna Inc. had expected via a roughly $590 million Biomedical Advanced Research and Development Authority award now looks to be off the table. The company disclosed May 28 that the U.S. Department of Health and Human Services (HHS) said it will terminate the award for late-stage development and right to purchase pre-pandemic influenza vaccines.
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Infection

Japanese scientists divulge new isoindoline compounds for viral infections

May 29, 2025
The Institute of Physical and Chemical Research and Kyoto University have synthesized isoindoline compounds reported to be useful for the treatment of viral infections.
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