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BioWorld - Monday, February 6, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
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Layoff illustration

Finch drops phase III of CP-101 for C. difficile, reduces staff by 95%

Jan. 24, 2023
By Karen Carey
No Comments
Microbiome company Finch Therapeutics Group Inc. has suffered one blow after another in the past year with dwindling cash, delayed programs, a terminated deal and three workforce reductions. The latest reduction will bring the once healthy 189-person company down to a handful of employees, and it places the lead program – the oral microbiota product, CP-101, for Clostridium difficile infection – on the sidelines.
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IC what you mean: ADAC nods to Cidara pre-panel review’s concerns but gives rezafungin thumbs up

Jan. 24, 2023
By Randy Osborne
No Comments
Albeit with complaints and provisos, the U.S. FDA’s Antimicrobial Drugs Advisory Committee (ADAC) rubber-stamped Cidara Therapeutics Inc.’s rezafungin, an injectable treatment for candidemia and invasive candidiasis (IC) in adults. Panelists were asked to vote on a single question: “Is the overall benefit-risk assessment favorable for the use of rezafungin for treatment of candidemia/IC in adults with limited or no alternative treatment options?” The balloting turned out 14 yes, one no.
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Infection

Chinese Academy of Sciences institutes divulge new compounds for infection and inflammatory disorders

Jan. 24, 2023
No Comments
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and Wuhan Institute of Virology of the Chinese Academy of Sciences have synthesized amide compounds reported to be useful for the treatment of dengue virus infection, skin inflammation, inflammatory joint disease, inflammatory bowel disease and autoimmune disease.
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Cidara brings rezafungin to an FDA adcom

Jan. 20, 2023
By Lee Landenberger
No Comments
Next week, Cidara Therapeutics Inc. will make its case for rezafungin, an injectable treatment for candidemia and invasive candidiasis in adults, before the U.S. FDA’s Antimicrobial Drugs Advisory Committee. When it convenes Jan. 24, the adcom will vote either yes or no if it believes the overall benefit-risk assessment is favorable for the use of rezafungin for treating candidemia/invasive candidiasis in adults with limited or no alternative treatment options.
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RNA strand
Drug Design, Drug Delivery & Technologies

Cas12a2 elicits abortive infection and can be repurposed as an RNA-guided RNA-targeting tool

Jan. 20, 2023
No Comments
Bacterial abortive infection is a defense mechanism by which an infected bacterial cell enters dormancy or dies to limit phage replication and protect the clonal population. Recent studies observed that CRISPR RNA-guided adaptive immune systems that target RNA also cause abortive-infection phenotypes by activating indiscriminate nucleases.
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Microscopic view of P. aeruginosa infection of mouse lung
Infection

What stops a bad guy in the lung? A good guy in the lung, of course

Jan. 20, 2023
By Anette Breindl
No Comments
Researchers at the Barcelona Institute of Science and Technology’s Center for Genomic Regulation (CRG) and Pulmobiotics Ltd. have used one bacterium to fight another. In mouse models, the team used engineered Mycoplasma pneumoniae to treat Pseudomonas aeruginosa, the chief culprit in ventilator-associated pneumonia (VAP).
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US FDA provides draft guidance on mpox drugs

Jan. 19, 2023
By Mari Serebrov
No Comments
Just as the U.S. mpox public health emergency declaration is about to end, the FDA is releasing a draft guidance on developing drugs and biologics to treat infections caused by the virus.
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US GAO: Improved oversight needed for high-risk research

Jan. 19, 2023
By Mari Serebrov
No Comments
The U.S. Department of Health and Human Services received low marks on its latest Government Accountability Office (GAO) report card for its oversight of high-risk research involving potential pandemic pathogens, but legislative fixes might be necessary to ensure that all the gaps are closed.
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Drug vial and syringe

Janssen shutters another HIV vaccine study

Jan. 19, 2023
By Lee Landenberger
No Comments
A year and a half gone, two HIV vaccine studies shut down. That’s the case with the Janssen Pharmaceutical Cos. of Johnson and Johnson as the phase III Mosaico study of its HIV vaccine regimen was not effective in preventing infection compared to placebo. Based on a data and safety monitoring board’s report saying the study was not expected to hit its primary endpoint, Janssen discontinued the clinical trial more than a year ahead of its estimated March 2024 completion date.
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Infection

Taxis Pharmaceuticals patents new antibacterial compounds

Jan. 19, 2023
No Comments
Taxis Pharmaceuticals Inc. has synthesized compounds reported to be useful for the treatment of bacterial infections.
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