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BioWorld - Monday, February 6, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
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Infection

Asieris Pharmaceuticals presents new compounds for urinary tract infections and cancer

Dec. 30, 2022
No Comments
Asieris Pharmaceuticals Co. Ltd. has divulged 7-nitro-8-hydroxyquinoline derivatives reported to be useful for the treatment of urinary tract infections, and bladder and prostate cancer.
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Transmission electron micrograph of hepatitis B virus particles
Infection

Researchers patent new heterocyclic compounds for HBV infection

Dec. 30, 2022
No Comments
Janssen R&D (Ireland) and Johnson & Johnson (China) Investment Ltd. have disclosed fused heterocyclic derivatives reported to be useful for the treatment of hepatitis B virus (HBV) infections.
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Vaccine vials and syringe in a martini glass.
Infection

‘22 in review: A toast to the future – of universal vaccines

Dec. 30, 2022
By Mar de Miguel
No Comments
Ice, juice, the exact measure of liquor, a few drops of Angostura... What goes into a good New Year’s Eve cocktail? According to researchers working on vaccines for the most elusive viruses, it will be time soon to toast next-generation vaccines. If 2020 was the year of the COVID-19 pandemic, and in 2021 the year of mRNA vaccinations, 2022 brought polyvalent designs of antigens, evaluated highly neutralizing antibodies, and fine-tuned mRNA technology against SARS-CoV-2, HIV and the flu.
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Hepatitus C virus
Infection

Permutated hepatitis C glycoprotein mosaic nanoparticle vaccine induces broad neutralizing antibody response

Dec. 29, 2022
No Comments
The hepatitis C virus (HCV) is so common that it infects approximately 0.7% of the world population to ultimately cause ~300,000 deaths each year. Small molecule-based antivirals can cure most HCV infections, but these are often only used after irreversible liver damage has already occurred, prohibitively expensive, and inaccessible for high-risk populations.
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Infection

3C-like proteinase (Mpro) inhibitors described in Pardes Biosciences patent

Dec. 28, 2022
No Comments
Pardes Biosciences Inc. has patented 3C-like proteinase (3CLpro; Mpro; nsp5) inhibitors (particularly HCoV-229E virus and/or SARS-CoV-2 Mpro inhibitors). They are reported to be potentially useful for the treatment of SARS-CoV-2 infections (COVID-19).
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Cytomegalovirus in a human cell

Takeda’s maribavir bested by valganciclovir in post-transplant CMV study

Dec. 27, 2022
By Tamra Sami
No Comments
Takeda Pharmaceutical Co. Ltd.'s oral antiviral, maribavir, failed to meet the primary endpoint of noninferiority compared to Roche Holding AG’s valganciclovir in the phase III Aurora study for cytomegalovirus (CMV) infection in hematopoietic stem cell transplant recipients. The multicenter, randomized, double-blind, double-dummy, active-controlled study was to form the basis for a future label expansion for the therapy.
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SARS-CoV-2 virus particles
Infection

Genetically attenuated SARS-CoV-2 protects against pneumonia in Syrian hamster model of COVID-19

Dec. 27, 2022
No Comments
Eleven vaccines have now been approved by the World Health Organization for preventing COVID-19, but all exhibit drastically reduced activities after 6 months. Unlike vaccines that express only the spike protein as the immunogen, live attenuated vaccines have the potential to confer a broader and more durable protection.
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Colorized transmission electron micrograph of SARS-CoV-2 (UK B.1.1.7 variant).
Immune

Oragenics reports toxicology findings with NT-CoV2-1 intranasal COVID-19 vaccine candidate

Dec. 23, 2022
No Comments
Oragenics Inc. has announced results from its...
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Cytomegalovirus in a human cell

Takeda’s maribavir bested by valganciclovir in post-transplant CMV study

Dec. 22, 2022
By Tamra Sami
No Comments
Takeda Pharmaceutical Co. Ltd.'s oral antiviral, maribavir, failed to meet the primary endpoint of noninferiority compared to Roche Holding AG’s valganciclovir in the phase III Aurora study for cytomegalovirus (CMV) infection in hematopoietic stem cell transplant recipients. The multicenter, randomized, double-blind, double-dummy, active-controlled study was to form the basis for a future label expansion for the therapy.
Read More
Sunlenca

Capsid audience: Gilead’s Sunlenca going where none has gone before in HIV

Dec. 22, 2022
By Randy Osborne
No Comments
Viral specialist Gilead Sciences Inc.’s U.S. FDA clearance for twice-yearly Sunlenca (lenacapavir) in combination with other antiretroviral therapies for HIV-1 infection provides heavily treatment-experienced patients a new option, and gives the company room to flex with new add-ons.
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