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Home » Topics » Disease categories and therapies » Infection

Infection
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HIV/AIDS

New HIV integrase inhibitors disclosed in Gilead patent

May 7, 2025
Gilead Sciences Inc. has divulged bridged tricyclic carbamoylpyridone prodrugs acting as HIV integrase inhibitors reported to be useful for the treatment of HIV infection.
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Tiger mosquito
Immune

Immunogenicity and efficacy of a bivalent self-amplifying RNA vaccine against yellow fever and Zika

May 7, 2025
No Comments
Researchers from the Access to Advanced Health Institute and collaborating institutions have developed a promising new bivalent vaccine candidate that can protect against both yellow fever and Zika viruses. The study demonstrates that the vaccine elicits robust humoral and cellular immune responses in mice and hamsters and provides complete protection against lethal viral challenges.
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Blood cells and bacteria

Deepull raises €50M for bloodstream infection test

May 1, 2025
By Shani Alexander
Deepull Diagnostics SL raised €50 million (US$56.93 million) in an oversubscribed series C financing round to complete clinical validation studies of its UllCORE diagnostic system for direct-from-blood rapid pathogen detection.
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US HHS touts NIH-developed universal vaccine platform

May 1, 2025
By Mari Serebrov
In a paradigm shift from private-sector partners, the U.S. Department of Health and Human Services (HHS) and the NIH announced May 1 the development of Generation Gold Standard, a next-generation, universal vaccine platform that uses a beta-propiolactone-inactivated, whole-virus to target pandemic-prone viruses.
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Illustrated diagram showing the various receptors of a natural killer cell
HIV/AIDS

Key genes and educated natural killer cells keep HIV in remission

April 30, 2025
By Mar de Miguel
Scientists at Institut Pasteur have gained new insights into how some people control HIV-1 replication after interruption of antiretroviral treatment (ART). The investigators found a fingerprint involved in long-term viral remission.
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Infection

Nuvobio divulges new peptides to treat C. neoformans infection

April 29, 2025
Nuvobio Corp. has synthesized peptides reported to be useful for the treatment of Cryptococcus neoformans infection.
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Infection

Ciprofloxacin prodrug effectively disrupts biofilm formation

April 29, 2025
Researchers from Foshan University described a ciprofloxacin prodrug designed to treat biofilm-associated drug-resistant P. aeruginosa infections.
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Drug vials and syringe

Vaccine Integrity Project launched to tackle ‘unfortunate reality’

April 25, 2025
By Nuala Moran
Nervousness about the Trump administration’s attitude to vaccines has spurred the formation of the Vaccine Integrity Project, which has the aim of safeguarding the use of vaccines and ensuring vaccine policy “remains grounded in the best available science,” and is “free from external influence.”
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Virus and drug illustration
Infection

GS-1 prevents varicella-zoster and herpes simplex virus entry

April 25, 2025
Varicella-zoster virus (VZV) causes chickenpox and shingles, while herpes simplex virus (HSV) is responsible for oral and genital herpes. Although current treatments mainly focus on inhibiting viral replication, there is a critical need for new therapies to address the limitations and side effects associated with existing treatments.
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Harvard University Widener Library

Harvard fighting back with lawsuit against Trump administration

April 23, 2025
By Nuala Moran
Harvard University has filed a lawsuit claiming the Trump administration’s freezing of its federal funding is unlawful and beyond the government’s authority. Announcing the move, Harvard’s president, Alan Garber, highlighted the impact of freezing $2.2 billion in grants – and the threat to freeze a further $1.1 billion – will have on the university’s biomedical research.
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