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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Inflammatory

Novel C3-targeting siRNA APL-3007 shows promising preclinical results in monkeys

Sep. 7, 2022
Dysregulation of complement activation plays a key role in the pathophysiology of several diseases, which makes it an attractive therapeutic target. C3 has an important role and central position within the signaling cascade, and is a potential target for therapy.
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Inflammatory

TQS-168 demonstrates geroprotective effects in mice

Aug. 30, 2022
Tranquis Therapeutics Inc. has announced preclinical data on the antiaging effects of TQS-168, a small-molecule modulator of PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator 1-alpha).
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Pill over molecule structures
ACS Fall 2022

Nimbus Therapeutics details discovery, discloses structure of selective TYK2 inhibitor NDI-034858

Aug. 30, 2022
The structure of a potent and selective TYK2 inhibitor, NDI-034858 (NTX-973), which was found clinically effective in autoimmune and inflammatory diseases, was disclosed for the first time by researchers from Nimbus Therapeutics LLC.
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Natural and synthetic embryos
Inflammatory

Researchers create mid-gestation embryos from stem cells

Aug. 26, 2022
By Nuala Moran
Researchers have created mouse embryos entirely from stem cells in vitro that formed a brain and a beating heart and lay the foundations for all the other organs of the body. The synthetic embryos faithfully mimic the development of their natural counterparts in utero for 8.5 days, before hitting a roadblock and becoming disorganized.
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Prazertherapeutics discovers MAPK p38 and nitric oxide production inhibitors

Aug. 25, 2022
Prazertherapeutics has discovered MAPK p38 and nitric oxide (NO) production inhibitors reported to be useful for the treatment of inflammation.
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Microbiome illustration

Bringing back butyrate is antigen-agnostic approach to food allergies

Aug. 24, 2022
By Anette Breindl
Treating mice with butyrate, a short-chain fatty acid that is normally produced by beneficial gut microbes, prevented anaphylactic shock in allergic mice when they were exposed to peanuts after treatment. It also reduced inflammation in animals with colitis.
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Microbiome illustration

Bringing back butyrate is antigen-agnostic approach to food allergies

Aug. 23, 2022
By Anette Breindl
Treating mice with butyrate, a short-chain fatty acid that is normally produced by beneficial gut microbes, prevented anaphylactic shock in allergic mice when they were exposed to peanuts after treatment. It also reduced inflammation in animals with colitis.
Read More

Antisense oligonucleotides targeting LINE-1 RNA could be used to treat premature aging

Aug. 17, 2022
Scientists have discovered an RNA-based mechanism that is involved in core hallmarks of a number of accelerated aging conditions and shown that therapies targeting this RNA reverses some of these hallmarks in human cells and extend life spans in mouse models.
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Australian coins and bills

Paradigm raises AU$66M to fund pivotal trials for Zilosul for pain associated with knee osteoarthritis

Aug. 16, 2022
By Tamra Sami
Paradigm Biopharmaceuticals Ltd. announced a AU$66 million (US$46.39 million) capital raise to fund its phase III pivotal trial for injectable Zilosul (pentosan polysulfate) to treat osteoarthritis of the knee.
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National Institute of Pharmaceutical R&D presents JAK-1 and/or TYK2 inhibitors

Aug. 10, 2022
The National Institute of Pharmaceutical R&D (Beijing) has described bridged heterocyclyl-substituted pyrimidine compounds acting as tyrosine-protein kinase JAK-1 and/or non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of inflammation, autoimmune disease and cancer.
Read More
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