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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Reindeer in snow
Dermatologic

Path to scarless healing could be among the gifts reindeer bring

Dec. 14, 2022
By Anette Breindl
Unlike amphibians, mammals do not regenerate appendages. Except when they do. “If you amputate one of the branches off of the antler [of a reindeer], it will also regenerate,” Jeff Biernaskie told BioWorld. Even without amputation, the antlers of both male and female reindeer regenerate annually, including their skin. That regeneration is “the only large mammal model of true skin regeneration,” he said.
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A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Endocrine/Metabolic

Suppression of the somatotrophic axis controls liver damage but produces fibrosis

Dec. 14, 2022
By Mar de Miguel
Liver damage arrests growth mediated by the somatotroph axis, which prevents liver cell death and inflammation, but increases fibrosis in nonalcoholic fatty liver disease (NAFLD). The explanation for this effect could lie in the relationship between the activating transcription factor 3 (ATF-3) and insulin-like growth factor 1 (IGF-1), according to a study from the University of California at Berkeley.
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Michael Henderson, CEO, Apogee Therapeutics

Apogee reaches for the top with $169M financing for antibody portfolio

Dec. 7, 2022
By Cormac Sheridan
Apogee Therapeutics Inc. emerged from stealth with $169 million in financing and a pipeline of four preclinical antibody development programs that take aim at major immunological and inflammatory disorders.
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Porphyromonas gingivalis

Keystone Bio linking oral health with systemic benefit

Dec. 5, 2022
By Cormac Sheridan
The age-old separation of dentistry from medicine is deeply embedded in education and professional practice. Given the great advances in both disciplines in recent decades, there is a reasonable argument to be made for maintaining the divide.
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Cancer

Reverse transcriptase inhibitors can prevent cancer drug resistance

Dec. 1, 2022
By Mar de Miguel
Retrotransposons could have a main role in the development of drug resistance in response to cancer treatment, according to a new study out of the Roswell Park Comprehensive Cancer Center. The transposition of DNA elements triggers an inflammatory response involved in the survival of cancer cells, a mechanism that could be blocked applying reverse transcriptase inhibitors, a class of drugs better known as anti-HIV medications.
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3D illustration of a nerve cell
Inflammatory

Novel TAK1 inhibitor alleviates inflammatory and neuropathic pain

Nov. 30, 2022
Researchers from Eydis Bio Inc. reported the discovery and preclinical characterization of a novel mitogen-activated protein kinase kinase kinase 7 (MAP3K7/TAK1) inhibitor, EYD-001, being developed for the treatment of inflammatory and neuropathic pain.
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C4X out-licenses preclinical NRF2 activator to Astrazeneca

Nov. 28, 2022
By Nuala Moran
C4X Discovery Holdings plc has outlicensed its once daily oral NRF2 (Nuclear factor-erythroid factor 2-related factor 2) activator to Astrazeneca plc in a deal with a potential value of $402 million. Of that, $2 million is being paid up front, with a further $14 million in preclinical milestones, which C4X CEO Clive Dix expects to trigger within the next two years.
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Arthritis pain illustration
Musculoskeletal

Silo Pharma to study binding affinity of SPU-21 in human synovial tissue for rheumatoid arthritis

Nov. 24, 2022
Silo Pharma Inc. plans to initiate a pilot study of SPU-21, its novel joint-homing peptide targeting rheumatoid arthritis (RA), in human synovial tissue surrounding joints and tendons.
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Inflammatory

DB-2306 demonstrates efficacy in models of autoimmune and inflammatory disease

Nov. 24, 2022
A research team at Duality Biologics (Suzhou) Co. Ltd. has discovered a novel anti-TNF-α monoclonal antibody-drug conjugate (ADC), DB-2306, as a potential therapeutic candidate for the treatment of autoimmune disease.
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Inflammatory

Sitryx Therapeutics patents new NRF2 activators for inflammatory disorders

Nov. 23, 2022
Sitryx Therapeutics Ltd. has disclosed 2-methylene-4-oxo-butanoic acid derivative compounds acting as nuclear factor erythroid 2-related factor 2 (NFE2-related factor 2; NFE2L2; NRF2) activators reported to be useful for the treatment of inflammatory disorders.
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