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BioWorld - Wednesday, June 11, 2025
Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Infection

Long lung COVID gives broader insights into fibrotic lung disease

Nov. 17, 2022
By Nuala Moran
An in-depth investigation of the underlying causes of pulmonary symptoms that in some cases persist for months following recovery from the acute stage of COVID-19 has found a distinctive proinflammatory signature in the plasma and airways of affected patients. The research could provide an explanation for the ongoing interstitial lung disease and fibrosis seen in patients who were hospitalized with severe COVID-19, and also point to neutrophils as a specific therapeutic target.
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Inflammatory

Medshine Discovery describes new BTK inhibitors for autoimmune diseases

Nov. 11, 2022
Medshine Discovery Inc. has identified imidazopyridine compounds acting as Bruton tyrosine kinase (BTK) inhibitors reported to be useful for the treatment of autoimmune diseases.
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Lab cultures of senescent human lung cells.
Immune

Low-dose checkpoint blockers have potential to slow aging processes

Nov. 10, 2022
By Tamra Sami
Low-dose administration of anti-PD-1 monoclonal antibodies could potentially reverse conditions associated with aging such as the accumulation of senescent cells and inflammation, according to a new study conducted at the Institute of Medical Science at the University of Tokyo.
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American Society of Nephrology

Certa Therapeutics’ FT-011 delivers breakthrough results in inflammatory, fibrotic diseases

Nov. 8, 2022
By Tamra Sami
New research presented by the University of Michigan revealed groundbreaking results for Certa Therapeutics Pty Ltd.’s lead candidate, FT-011, for serious inflammatory and fibrotic diseases.
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Multiple sclerosis
Neurology/Psychiatric

Dual MAO-B and SSAO inhibitor exhibits ideal in vitro ADME characteristics, appears to be a potentially promising anti-inflammatory therapeutic

Nov. 7, 2022
Monoamine oxidase B (MAO-B) and...
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American Society of Nephrology

Certa Therapeutics’ FT-011 delivers breakthrough results in inflammatory, fibrotic diseases

Nov. 4, 2022
By Tamra Sami
New research presented by the University of Michigan revealed groundbreaking results for Certa Therapeutics Pty Ltd.’s lead candidate, FT-011, for serious inflammatory and fibrotic diseases. The results of a chronic kidney disease study presented at the American Society of Nephrology meeting on Nov. 4 concluded that FT-011 reverses the activation of molecular markers associated with fibrosis.
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Intestine
Inflammatory

Saniona completes preclinical development of SAN-903 for inflammatory and fibrotic diseases

Nov. 4, 2022
Saniona AB has completed preclinical development with SAN-903 and is ready to start the regulatory process for entering phase I trials either alone or together with a partner. SAN-903 is a novel, potential first-in-class medicine based on inhibition of the calcium-activated potassium ion channel KCa3.1.
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Biomarkers

Transcription factors define rheumatoid arthritis subtypes

Oct. 26, 2022
By Anette Breindl
Based on an analysis of critical transcription factors, researchers have stratified rheumatoid arthritis (RA) into two subtypes where gene expression was driven by RAR-α or TGF-β, respectively. The findings, published in Nature Communications on Oct. 20, 2022, by researchers from the University of California, San Diego, give new insights into factors that affect the treatment response in RA, and could point to novel treatment strategies.
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SARS-CoV-2 virus particles
Infection

At IDWeek, new insights into long COVID

Oct. 21, 2022
By Mar de Miguel
Three years after WHO declared the COVID-19 pandemic, some patients are still reporting symptoms from long-ago infections. And the scientific community is studying the reasons for the post-acute sequelae of SARS-CoV-2 (PASC). Until now, the studies provided varied reasons related to persistent COVID or PASC, such as acute SARS-CoV-2 injury in different organs, or reservoirs of the virus in certain tissues, as it happens with other pathogens like HIV. At the IDWeek 2022 infectious disease conference held this week in Washington, D.C., Eric Daar, chief of the Division of HIV Medicine at the Lundquist Institute at Harbor-UCLA Medical Center, moderated the session, 'COVID-19: Post-acute sequelae', where talks offered new results on the symptoms of people who have suffered prolonged COVID during the pandemic.
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Genetic/congenital

Bioage Labs identifies new NLRP3 inflammasome inhibitors

Oct. 20, 2022
Bioage Labs Inc. has synthesized new NLRP3 inflammasome inhibitors reported to be useful for the treatment of cryopyrin-associated periodic syndromes, hearing loss, Ménière's disease, tinnitus, vertigo and inflammatory disorders.
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