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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Greater horseshoe bats hanging in cave
Infection

Bat cell line reveals unusual molecular relationship with viruses

Feb. 28, 2023
By Helen Albert
An international team of researchers has created two bat stem cell lines that reveal an unusual number of viral sequences in bat cells compared with those of other mammals. Writing in an article posted online Feb. 21, 2023, in Cell, the scientists suggested that the unusual amount of viral genetic material found in the bat stem cells could explain why these mammals are largely unaffected by most viral infections, despite being able to transmit them.
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Table with foods that commonly cause allergic reactions
Immune

Immunomodulatory peptide IRL-201104 shows long-lasting efficacy in murine model of food allergy

Feb. 28, 2023
Researchers from Revolo Biotherapeutics Ltd. have presented preclinical data for IRL-201104, a clinical-stage immunomodulatory peptide that has previously demonstrated a long-lasting effect in different preclinical models of allergic inflammation. In the new studies, the candidate was assessed in models of food allergy.
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Mast cell
Inflammatory

AK-006 anti-Siglec-6 MAb suppresses mast cell activity in several models

Feb. 28, 2023
Mast cells (MCs) are one of the key drivers of acute and chronic inflammation and can be activated...
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Yen-Yuan symbols

Transthera raises $38M, propelling TT-0420 toward market

Feb. 27, 2023
By Doris Yu
Transthera Sciences Inc., a Nanjing, China-based company developing small-molecule therapies in cancer, inflammation and cardiovascular disease, raised ¥260 million (US$38 million) in a series D+ funding round to advance its first drug product.
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Drug R&D concept image.
Ocular

Aldeyra advances RASP modulators ADX-246 and ADX-248 toward clinic

Feb. 24, 2023
Aldeyra Therapeutics Inc. is eyeing the start of clinical trials with reactive aldehyde species (RASP) modulators ADX-246 for systemic immune-mediated diseases and ADX-248 for geographic atrophy.
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Joint pain
Musculoskeletal

Anti-TNF/IL-6 nanobody shows sustained and synergic in vitro and in vivo efficacy in rheumatoid arthritis

Feb. 22, 2023
Antibodies against tumor necrosis factor (TNF) and IL-6 receptor are the most effective available therapies against rheumatoid arthritis (RA). However, no cure for RA exists. In work published in Science Translational Medicine, scientists from Sanofi R&D (Sanofi SA) investigated whether dual inhibition of TNF and IL-6 could improve the therapeutic efficacy against RA.
Read More
Greater horseshoe bats hanging in cave
Infection

Bat cell line reveals unusual molecular relationship with viruses

Feb. 22, 2023
By Helen Albert
An international team of researchers has created two bat stem cell lines that reveal an unusual number of viral sequences in bat cells compared with those of other mammals. Writing in an article posted online Feb. 21, 2023, in Cell, the scientists suggested that the unusual amount of viral genetic material found in the bat stem cells could explain why these mammals are largely unaffected by most viral infections, despite being able to transmit them.
Read More
Microbiome illustration
Gastrointestinal

Intestinal oxygen protects against GVHD via microbiome

Feb. 16, 2023
When oxygen levels of the intestine increase, the appropriate hypoxic conditions for intestinal microbiota are lost. This state may be caused by immune-mediated malfunction of the intestinal epithelium. By controlling oxygen levels, the imbalance in the intestinal microbiome (dysbiosis) can be reduced.
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Scientist with vial
Inflammatory

Coya gains rights to develop COYA-301 for autoimmune diseases

Feb. 16, 2023
Coya Therapeutics Inc. has announced expansion of its exclusive worldwide rights for the development and commercialization of COYA-301, the company's low-dose IL-2 subcutaneous administration product candidate. COYA-301 is intended to enhance regulatory T-cell (Treg) function in vivo to treat the systemic neuro-inflammation underlying certain autoimmune and neurodegenerative diseases.
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3D Euro symbol

Merck signs on to Aqilion’s autoimmune project in €960M deal

Feb. 16, 2023
By Caroline Richards
Aqilion AB has sold rights to its TAK1 inhibitors to Merck KGaA in an exclusive license and research collaboration agreement worth at least €960 million (US$1.03 billion) including potential milestones and royalties. The global giant will pay the Swedish biotech – which is headquartered in Helsingborg – €10 million in cash up front for the program and potential development and commercialization milestones and tiered royalties on worldwide net sales of more than €950 million.
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