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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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3D molecular model illustration of RIPK1
Inflammatory

Novel sibiriline derivative KWCN-41 shows anti-necroptosis effect

March 28, 2023
Necroptosis is a well-controlled process of programmed necrosis present in inflammatory disorders mainly regulated by RIPK1, RIPK3 and mixed-lineage kinase domain-like pseudokinase (MLKL).
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Drug R&D concept image.
Cancer

Captor Therapeutics outlines pipeline progress

March 28, 2023
Captor Therapeutics SA has offered an update on its lead programs CT-01, CT-02 and CT-05. In the CT-01 program, CPT-6281 is currently undergoing IND/CTA-enabling studies with the first clinical trial expected to start at the end of the year. The first indication will be in hepatocellular carcinoma (HCC).
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Human cell illustration
Inflammatory

Atyr Pharma’s tRNA synthetase candidate ATYR-0101 binds to fibrosis target LTBP-1

March 28, 2023
Researchers from Atyr Pharma Inc. presented findings from the innovative tRNA synthetase platform, highlighting ATYR-0101, a potential therapeutic biologic based on a domain appended to aspartyl-tRNA synthetase (DARS).
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Illustration of leg anatomy with target around knee
Inflammatory

Partially blocking inflammatory receptor could lead to treatment for osteoarthritis

March 24, 2023
By Helen Albert
Partially blocking a receptor that helps regulate the activity of the inflammatory cytokine molecule interleukin-6 (IL-6) seems to promote tissue regeneration and block degeneration in a model of osteoarthritis. As reported in the March 22, 2023, issue of Science Translational Medicine, the receptor, called glycoprotein 130 (gp130), regulates both positive and negative inflammatory responses that can help regenerate tissue, but also cause degeneration.
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Representative images of MMP-12 stained (magenta) human kidney biopsies.
Nephrology

T cells initiate kidney inflammation in glomerulonephritis

March 22, 2023
By Mar de Miguel
A study from the University Medical Center Hamburg-Eppendorf (UKE) in Germany has identified a type of T cell that triggered glomerulonephritis (GN) and produced loss of kidney function in mice. The scientists described an autoimmune pathway of this disease mediated by the accumulation of T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) in the kidneys and found a possible therapeutic target.
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Foot pain

Gout doubts Dissolve with dual phase III outcomes from Selecta, Sobi

March 21, 2023
By Randy Osborne
Selecta Biosciences Inc. and Swedish Orphan Biovitrum AB unveiled top-line phase III data from the Dissolve I and II trials testing SEL-212 in adults with chronic refractory gout (CRG) – results that position the companies for a regulatory filing in the U.S. during the first half of next year. SEL-212 could take on Horizon Therapeutics plc’s Krystexxa (pegloticase), a pegylated uric acid specific enzyme cleared by the U.S. FDA for CRG in September 2010.
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Inflammatory

Reistone Biopharma divulges new MK2 inhibitors

March 20, 2023
Reistone Biopharma Co. Ltd. has synthesized quinolinofuran derivatives acting as MAP kinase-activated protein kinase 2 (MAPKAPK2; MK2) inhibitors reported to be useful for the treatment of fibrosis, autoimmune, inflammatory and metabolic disorders.
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Inflammatory

Redx Pharma divulges DDR1 and DDR2 inhibitors

March 15, 2023
Redx Pharma plc has described henyl- and pyridopyrazole derivatives as discoidin domain-containing receptor DDR1 and/or DDR2 inhibitors. They are reported to be useful for the treatment of fibrosis, cancer, transplant rejection, inflammatory, renal, liver and cardiovascular disorders.
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Respiratory

Tetra Bio-Pharma's oral ARDS-003 cleared by Health Canada to enter clinic

March 13, 2023
Tetra Bio-Pharma Inc. has received clearance from Health Canada to proceed with a first-in-human trial in Canada using oral ARDS-003 (onternabez) to treat various immunomodulatory conditions. Oral ARDS-003 is positioned to modulate acute systemic inflammation and prevent sepsis, acute respiratory distress syndrome (ARDS) and organ damage.
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Lungs
Inflammatory

Discovery of novel anti-inflammatory agents with efficacy in models of acute lung injury and sepsis

March 10, 2023
Researchers from Wenzhou Medical University and affiliated organizations presented the discovery of novel anti-inflammatory agents. Synthesis and optimization of a series of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives led to the identification of compound [I] as the lead, as it exhibited the best inhibitory effect in vitro. More specifically, [I] demonstrated the strongest inhibitory effect on LPS-induced TNF-α (82.58%) and IL-6 (75.05%) expression, while exhibiting no cytotoxicity at 10 μM in J774A.1 macrophages.
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