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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

Humanwell Healthcare patents new 15-PGDH inhibitors

May 26, 2023
Research at Humanwell Healthcare (Group) Co. Ltd. has led to the development of heterocyclic 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors reported to be useful for the treatment of acute lung injury, diabetes, fibrosis, graft-vs.-host disease, heart failure, inflammatory bowel disease, alopecia and osteoporosis, among others.
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Art concept for inflamed human tissue
Inflammatory

LTB4 antagonist shows efficacy in rat inflammation model

May 26, 2023
Cellular mediators like cytokines that are released as a reaction to cell injury or excessive stimulation can lead to the synthesis of chemotactic eicosanoid leukotriene B4 (LTB4) among others. This mediator acts as a potent chemokine promoting migration of macrophages and neutrophils into tissues during inflammation. Researchers from CNRS, Universitat de Barcelona and colleagues reported the synthesis and evaluation of new 1,4-benzodioxine derivatives with selective LTB4 antagonism activity that led to the identification of [I] as the lead compound, which had higher affinity for LTB4 receptor with an IC50 value of 288 nM.
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Inflammatory

Bristol Myers Squibb patents RXFP1 agonists

May 23, 2023
Several recent Bristol Myers Squibb Co. patents cover relaxin receptor 1 (RXFP1; LGR7) agonists...
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Obesity, fat cell research concept image
Inflammatory

Researchers optimize biphenyl scaffold molecules as potent FABP4 inhibitors

May 23, 2023
The fatty-acid binding proteins are lipid chaperones involved in lipid-mediated biological...
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Joint pain
Inflammatory

FPR1 antagonist AZ-2158 more potent than cyclosporin H

May 19, 2023
Formyl peptide receptor 1 (FPR1) is a G protein...
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Antibodies
Inflammatory

CDX-622, a bispecific antibody targeting SCF and TSLP

May 19, 2023
Stem cell factor (SCF) is a ligand of the KIT...
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Inflammatory

Huchembio discovers new STAT3 inhibitors

May 18, 2023
Huchembio Co. Ltd. has described signal transducer and activator of transcription 3 (STAT3) inhibitors reported to be useful for the treatment of autoimmune diseases, atherosclerosis, inflammatory disorders, cancer, diabetic retinopathy, diabetes, osteoporosis and viral infections.
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Art concept for inflamed human tissue
Inflammatory

ON-104 demonstrates efficacy in preclinical models of chronic inflammatory disease

May 16, 2023
Researchers from Oncoone Research & Development GmbH have presented preclinical...
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Respiratory

Innate, adaptive, trained immunity contribute to asthma development

May 16, 2023
By Anette Breindl
Researchers have compared the cellular responses driving allergic asthma to those in individuals with allergic rhinitis and conjunctivitis but no allergic response in the lungs. Asthma is “an umbrella term,” Josalyn Cho told BioWorld. But under that umbrella, the largest group of people are those whose asthma begins in childhood. And “those folks almost exclusively develop their asthma after they develop allergies.”
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Gold dollar sign inside gold cog

Lucrative Arcus, Gilead alliance expands into inflammatory disease

May 15, 2023
With much-awaited readouts from their broad oncology-focused collaboration due later this year, Arcus Biosciences Inc. and Gilead Sciences Inc. have decided to expand efforts into the inflammatory disease space via an early stage research agreement that could be worth as much as $1 billion. Terms include a $35 million up-front payment to Arcus, which is making its first move beyond oncology.
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