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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Thrombus in bloodstream with platelets and fibrin
Newco news

Calida Therapeutics raises $2.17M to advance thrombo-inflammatory research

April 13, 2023
By Caroline Richards
With the backing of €2 million (US$2.17 million) in seed funding from venture capital company Adbio partners, French biotech Calida Therapeutics hopes that drawing on some U.S. academic research into thrombo-inflammatory disorders will enable it to develop a series of monoclonal antibodies.
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Biomarkers

Tyrosine-protein kinase Lyn behind liver fibrosis and cutaneous vasculitis

April 6, 2023
Investigators from the National Institute of Allergy and Infectious Diseases have reported data on a series of 3 patients with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation, with 2 of them developing liver fibrosis in the first year of their lives.
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Inflammatory

Japan Tobacco describes NLRP3 inflammasome inhibitors

March 30, 2023
Research at Japan Tobacco Inc. has led to the development of 6-aminopyrazolopyrimidine compounds acting as NLRP3 inflammasome inhibitors and reported to be useful for the treatment of arteriosclerosis, gout, inflammatory bowel disease, amyotrophic lateral sclerosis, multiple sclerosis, nonalcoholic steatohepatitis (NASH), Alzheimer’s and Parkinson’s diseases.
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3D molecular model illustration of RIPK1
Inflammatory

Novel sibiriline derivative KWCN-41 shows anti-necroptosis effect

March 28, 2023
Necroptosis is a well-controlled process of programmed necrosis present in inflammatory disorders mainly regulated by RIPK1, RIPK3 and mixed-lineage kinase domain-like pseudokinase (MLKL).
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Drug R&D concept image.
Cancer

Captor Therapeutics outlines pipeline progress

March 28, 2023
Captor Therapeutics SA has offered an update on its lead programs CT-01, CT-02 and CT-05. In the CT-01 program, CPT-6281 is currently undergoing IND/CTA-enabling studies with the first clinical trial expected to start at the end of the year. The first indication will be in hepatocellular carcinoma (HCC).
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Human cell illustration
Inflammatory

Atyr Pharma’s tRNA synthetase candidate ATYR-0101 binds to fibrosis target LTBP-1

March 28, 2023
Researchers from Atyr Pharma Inc. presented findings from the innovative tRNA synthetase platform, highlighting ATYR-0101, a potential therapeutic biologic based on a domain appended to aspartyl-tRNA synthetase (DARS).
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Illustration of leg anatomy with target around knee
Inflammatory

Partially blocking inflammatory receptor could lead to treatment for osteoarthritis

March 24, 2023
By Helen Albert
Partially blocking a receptor that helps regulate the activity of the inflammatory cytokine molecule interleukin-6 (IL-6) seems to promote tissue regeneration and block degeneration in a model of osteoarthritis. As reported in the March 22, 2023, issue of Science Translational Medicine, the receptor, called glycoprotein 130 (gp130), regulates both positive and negative inflammatory responses that can help regenerate tissue, but also cause degeneration.
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Representative images of MMP-12 stained (magenta) human kidney biopsies.
Nephrology

T cells initiate kidney inflammation in glomerulonephritis

March 22, 2023
By Mar de Miguel
A study from the University Medical Center Hamburg-Eppendorf (UKE) in Germany has identified a type of T cell that triggered glomerulonephritis (GN) and produced loss of kidney function in mice. The scientists described an autoimmune pathway of this disease mediated by the accumulation of T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) in the kidneys and found a possible therapeutic target.
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Foot pain

Gout doubts Dissolve with dual phase III outcomes from Selecta, Sobi

March 21, 2023
By Randy Osborne
Selecta Biosciences Inc. and Swedish Orphan Biovitrum AB unveiled top-line phase III data from the Dissolve I and II trials testing SEL-212 in adults with chronic refractory gout (CRG) – results that position the companies for a regulatory filing in the U.S. during the first half of next year. SEL-212 could take on Horizon Therapeutics plc’s Krystexxa (pegloticase), a pegylated uric acid specific enzyme cleared by the U.S. FDA for CRG in September 2010.
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Inflammatory

Reistone Biopharma divulges new MK2 inhibitors

March 20, 2023
Reistone Biopharma Co. Ltd. has synthesized quinolinofuran derivatives acting as MAP kinase-activated protein kinase 2 (MAPKAPK2; MK2) inhibitors reported to be useful for the treatment of fibrosis, autoimmune, inflammatory and metabolic disorders.
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