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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Drug R&D concept image.
Inflammatory

BITT advances Domab-based programs

Feb. 14, 2023
Boston Immune Technologies and Therapeutics Inc. (BITT) has announced progress using its Domab platform. Two Domab CD40 antagonists, BITT-CD4D11 and BITT-CD4F10, have completed discovery and optimization and a final candidate is being selected for IND-enabling steps.
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Cancer

Conversation between telomeres and mitochondria about aging prevents cancer

Feb. 13, 2023
By Mar de Miguel
Researchers from The Salk Institute have described a signaling pathway that sets off an unusual, autophagy-dependent cell death mechanism as a fail-safe for cells that have evaded senescence mechanisms. The scientists found a tumor suppression mechanism mediated by telomere signaling, which activated an innate immune response through mitochondrial and telomere complexes to eliminate cells with shortened telomeres.
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Inflammatory

Researchers present new cGAS inhibitors

Feb. 10, 2023
Scripps Research Institute and Shangpharma Innovation have divulged cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors reported to be useful for the treatment of autoinflammatory interferonopathy, autoimmune and neurological disorders.
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Gastrointestinal

MaR2 thermostable nanoparticles promote mucosal repair in inflammatory disease

Feb. 10, 2023
Maresin-2 (MaR2) is a bioactive lipid derived from omega-3 polyunsaturated fatty acid.
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Inflammatory

Discovery of new COX-2 inhibitors with promising anti-inflammatory activity in vivo

Feb. 8, 2023
Researchers from Jouf University and affiliated organizations have reported the discovery of novel cyclooxygenase-2 (COX-2) inhibitors as potential nonacidic anti-inflammatory agents.
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Pen and ripped contract

Kyocera pulls out of Regeneus deal for stem cell therapy Progenza for osteoarthritis

Feb. 7, 2023
By Tamra Sami
In a blow to Aussie regenerative medicine company Regeneus Ltd., Japan’s Kyocera Corp. has pulled out of a licensing deal for Regeneus’ lead mesenchymal stem cell (MSC) therapy, Progenza, for osteoarthritis of the knee for the Japan market.
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Macrophage releasing cytokines as a part of the body's immune response.
Inflammatory

Inmagene to advance its long-acting IL-36R monoclonal antibody IMG-008

Feb. 6, 2023
Inmagene Biopharmaceuticals Co. Ltd. has obtained IND approval from the FDA for IMG-008, the company's novel long-acting antagonistic humanized monoclonal antibody that specifically targets human IL-36 receptor (IL-36R) to treat auto-inflammatory diseases.
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Inflammatory

Philadelphia University describes new COX-2 inhibitors

Feb. 3, 2023
Philadelphia University (Jordan) has synthesized 2,4-disubstituted-thieno[2,3-d]pyrimidines acting as prostaglandin G/H synthase 2 (COX-2) inhibitors.
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Pen and ripped contract

Kyocera pulls out of Regeneus deal for stem cell therapy Progenza for osteoarthritis

Feb. 2, 2023
By Tamra Sami
In a blow to Aussie regenerative medicine company Regeneus Ltd., Japan’s Kyocera Corp. has pulled out of a licensing deal for Regeneus’ lead mesenchymal stem cell (MSC) therapy, Progenza, for osteoarthritis of the knee for the Japan market. Osteoarthritis of the knee is the first indication for Progenza, an allogeneic off-the-shelf adipose-derived MSC therapy.
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Inflammatory

Prazer Therapeutics presents new MAPK14 inhibitors

Feb. 1, 2023
Prazer Therapeutics Inc. has identified mitogen-activated protein kinase 14 (MAPK14) inhibitors reported to be useful for the treatment of inflammatory disorders.
Read More
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