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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Lungs
Respiratory

MCEMP1, a KIT receptor adaptor promoting mast cell proliferation in chronic airway inflammation

April 28, 2023
Mast cell-expressed membrane protein 1 (MCEMP1) is a type II transmembrane protein predominantly expressed in myeloid lineage immune cells, including lung-resident mast cells and alveolar macrophages. MCEMP1 is a critical factor in allergic and inflammatory lung diseases, with higher expression levels correlating with increased disease severity. However, the molecular mechanisms underlying the role of MCEMP1 in the pathogenesis of lung inflammatory diseases remain unclear.
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3D dollar sign
Newco news

Albatroz launches with $3M in seed funding to tackle new target for solid tumors and arthritis

April 26, 2023
By Tamra Sami
Albatroz Therapeutics Pte Ltd. has secured $3 million in seed funding to develop therapeutic antibodies against a new target that degrades the extracellular matrix, a key contributor to cancer and arthritis.
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Inflammatory

Viva Star Biosciences patent reveals NLRP3 inflammasome inhibitors

April 26, 2023
Viva Star Biosciences (Suzhou) Co. Ltd. has identified substituted sulfonylurea compounds acting as NLRP3 inflammasome inhibitors and reported to be useful for the treatment of cryopyrin-associated periodic syndrome, multiple sclerosis, atherosclerosis, type 2 diabetes, osteoarthritis, cancer, Alzheimer’s and Parkinson’s disease.
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Inflammatory

Yuhan Corp. reports development of new LOXL2 inhibitors

April 24, 2023
Lysyl oxidase homologue 2 (LOXL2) inhibitors have been reported in a Yuhan Corp. patent as potentially useful for the treatment of idiopathic pulmonary fibrosis, nonalcoholic steatohepatitis (NASH), chronic kidney disease and cirrhosis.
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Inflammatory

Janssen Pharmaceutica describes new IL-17 production inhibitors for inflammatory disorders

April 20, 2023
Janssen Pharmaceutica NV has identified IL-17 production inhibitors reported to be useful for the treatment of inflammatory disorders.
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Microscopic image of nodes of Ranvier in the myelin sheath
Neurology/Psychiatric

Mature oligodendrocytes play minor role in remyelination

April 20, 2023
By Mar de Miguel
The loss of myelin in the cerebral cortex of multiple sclerosis (MS) patients could be recovered if oligodendrocytes, the cells that myelinate neuronal axons, work at a higher rate than they are destroyed. However, a group of scientists from the University of Munich have shown, in cortical MS mice, that this does not occur. The oligodendrocytes do not contribute to remyelination efficiently.
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Firefighter conducting prescribed burn
Cancer

AACR 2023: Myeloid cell biology is 'growth area' for antitumor immunity

April 19, 2023
By Anette Breindl
Antitumor immunotherapy has notched big wins, but in a small proportion of patients. And one possible explanation for why is that approved immunotherapies are not yet planting their flag on most of the battlefields where tumors and the immune system engage in combat. At the opening AACR 2023 plenary session, Ralph DeNardo celebrated the successes of the current, mostly T-cell-based approaches,  but also encouraged his colleagues to think more broadly about the antitumor immunity.
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Thrombus in bloodstream with platelets and fibrin
Newco news

Calida Therapeutics raises $2.17M to advance thrombo-inflammatory research

April 13, 2023
By Caroline Richards
With the backing of €2 million (US$2.17 million) in seed funding from venture capital company Adbio partners, French biotech Calida Therapeutics hopes that drawing on some U.S. academic research into thrombo-inflammatory disorders will enable it to develop a series of monoclonal antibodies.
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Biomarkers

Tyrosine-protein kinase Lyn behind liver fibrosis and cutaneous vasculitis

April 6, 2023
Investigators from the National Institute of Allergy and Infectious Diseases have reported data on a series of 3 patients with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation, with 2 of them developing liver fibrosis in the first year of their lives.
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Inflammatory

Japan Tobacco describes NLRP3 inflammasome inhibitors

March 30, 2023
Research at Japan Tobacco Inc. has led to the development of 6-aminopyrazolopyrimidine compounds acting as NLRP3 inflammasome inhibitors and reported to be useful for the treatment of arteriosclerosis, gout, inflammatory bowel disease, amyotrophic lateral sclerosis, multiple sclerosis, nonalcoholic steatohepatitis (NASH), Alzheimer’s and Parkinson’s diseases.
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