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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Respiratory

Innate, adaptive, trained immunity contribute to asthma development

May 16, 2023
By Anette Breindl
Researchers have compared the cellular responses driving allergic asthma to those in individuals with allergic rhinitis and conjunctivitis but no allergic response in the lungs. Asthma is “an umbrella term,” Josalyn Cho told BioWorld. But under that umbrella, the largest group of people are those whose asthma begins in childhood. And “those folks almost exclusively develop their asthma after they develop allergies.”
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Gold dollar sign inside gold cog

Lucrative Arcus, Gilead alliance expands into inflammatory disease

May 15, 2023
With much-awaited readouts from their broad oncology-focused collaboration due later this year, Arcus Biosciences Inc. and Gilead Sciences Inc. have decided to expand efforts into the inflammatory disease space via an early stage research agreement that could be worth as much as $1 billion. Terms include a $35 million up-front payment to Arcus, which is making its first move beyond oncology.
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Drug R&D concept image.
Gastrointestinal

Absci and University of Oxford partner on discovery and development of therapies for immune-mediated diseases

May 12, 2023
Absci Corp. and the University of Oxford’s...
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COVID-19 mRNA vaccine vials, syringe
Cardiovascular

COVID vaccine myocarditis is due to inflammation

May 9, 2023
By Anette Breindl
By analyzing a cohort of adolescents that developed myocarditis or pericarditis after vaccination against SARS-CoV-2 vaccination, researchers from Yale University School of Medicine were able to pinpoint the underlying mechanism as an overly active innate immune response to the vaccine that led to broad activation of T cells and natural killer (NK) cells. Myocarditis “has been seen in other vaccine contexts, though is most common after viral infection,” Carrie Lucas told reporters at a press conference announcing the findings.
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3D dollar sign
Newco news

Albatroz launches with $3M in seed funding to tackle new target for solid tumors and arthritis

May 2, 2023
By Tamra Sami
Albatroz Therapeutics Pte Ltd. has secured $3 million in seed funding to develop therapeutic antibodies against a new target that degrades the extracellular matrix, a key contributor to cancer and arthritis.
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Inflammatory

Profibrotic macrophages identified in lung and liver fibrosis

May 2, 2023
Macrophages, a cell type involved in the inflammatory response, are also responsible for collagen deposition in lung and liver fibrosis. In a recently published study, researchers identified a subpopulation of profibrotic macrophages.
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Lab glassware and scientist
Inflammatory

Vyne selects development candidate from BD2-selective BET inhibitor program for immuno-inflammatory conditions

May 2, 2023
Vyne Therapeutics Inc. has selected a development candidate, VYN-202, for its oral BD2-selective bromodomain and extra-terminal (BET) inhibitor program for the treatment of immuno-inflammatory conditions.
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Illustration of interleukin-2 protein structure
Cancer

Pancreatic cancer immunotherapy treatment shows early promise

May 2, 2023
By Helen Albert
A novel bispecific immunotherapy developed by Roche AG to target pancreatic cancer showed promising results combined with radiation therapy in preclinical trials carried out at the University of Colorado.
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Inflammatory

Series A financing at Therini Bio funds fibrin-targeted therapies for neurodegenerative and retinal diseases

April 28, 2023
Therini Bio Inc. has closed a US$36 million series A financing round that will support its work on developing fibrin-targeted therapies for diseases driven by chronic inflammation, including Alzheimer’s disease, multiple sclerosis and retinal diseases such as diabetic macular edema.
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Lungs
Respiratory

MCEMP1, a KIT receptor adaptor promoting mast cell proliferation in chronic airway inflammation

April 28, 2023
Mast cell-expressed membrane protein 1 (MCEMP1) is a type II transmembrane protein predominantly expressed in myeloid lineage immune cells, including lung-resident mast cells and alveolar macrophages. MCEMP1 is a critical factor in allergic and inflammatory lung diseases, with higher expression levels correlating with increased disease severity. However, the molecular mechanisms underlying the role of MCEMP1 in the pathogenesis of lung inflammatory diseases remain unclear.
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