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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Heart illustration
Cardiovascular

Inflammation-resolving compound has protective effects in myocardial infarction model

July 14, 2023
The endogenous human protein annexin A1 (ANXA1) is a driver of inflammatory resolution and has shown protective effects in several models of diseases with inflammatory components, including myocardial infarction. Researchers from Resother Pharma A/S and colleagues reported on the preclinical cardioprotective role of RTP-026, a peptide derived from the ANXA1 N-terminal region that acts as N-formyl peptide receptor 2 (FPR2) ligand. In vitro, testing of receptor selectivity and activation in FPR2-HEK-293 cells showed an EC50 value between 10 and 30 nM.
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Inflammatory

Antisense targeting of NLRP3 favorably reduces inflammasome activity, increases survival in preclinical mouse model of CAPS

July 13, 2023
The nucleotide-binding and oligomerization domain-like receptor family pyrin domain...
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Lungs
Inflammatory

Novel amide compound shows anti-inflammatory activity in models of LPS-induced ALI and sepsis

July 13, 2023
Researchers from Wenzhou Medical University and affiliated organizations have reported the...
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Scientific figure illustrating astrocytes and neuron synapse
Neurology/Psychiatric

Glial cells get all-too-rare star turn at biannual meeting

July 13, 2023
By Anette Breindl
In brain research, be it basic or clinical, neurons have long hogged the limelight. But at the 2023 European Meeting on Glial Cells in Health and Disease, neurons take a back seat to glia – cell types that have often been described as support cells and treated as an afterthought, but that play critical roles in all aspects of brain function, including information processing.
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Inflammatory

Orixa Therapeutics patents new PR3 and ELANE inhibitors

July 12, 2023
Orixa Therapeutics LLC has disclosed small...
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Inflammatory

ADS-032, dual NLRP1 and NLRP3 inflammasome inhibitor with efficacy in models of pulmonary inflammation and infection

July 11, 2023
Researchers from Adiso Therapeutics Inc. have reported the discovery of a novel small-molecule dual NLRP1 and NLRP3 inflammasome inhibitor, ADS-032, being developed for the treatment of inflammatory diseases. Screening of an in-house bioactive compound library led to the discovery of ADS-032, a sulfonylurea compound.
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Close up of senior man holding wrist of arthritic hand
Musculoskeletal

Discovery of novel VEGFR-2 kinase inhibitor with promising antiarthritic and antiangiogenic properties

July 7, 2023
Researchers from Anhui Medical University presented the discovery and preclinical evaluation of new vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors as potential therapeutic candidates for rheumatoid arthritis.
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Art concept for inflamed human tissue
Inflammatory

New chiral pyrazolo isoquinoline derivatives with promising anti-inflammatory properties reported

July 3, 2023
Natural compounds derived from quinoline and isoquinoline have gained significant attention due to their remarkable biological properties, encompassing antibacterial, anticancer and anti-inflammatory activities. Meanwhile, pyrazoles, a prominent class of heterocyclic compounds, exhibit a wide range of biological and pharmaceutical properties.
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T cells
Inflammatory

ANB-033, a novel anti-human CD122 MAb for T-cell-mediated inflammatory autoimmune disorders

June 29, 2023
CD122 signaling plays a key role in the function of CD4, CD8 T cells and natural killer (NK) cells, as well as in the development and survival of tissue-resident memory T cells (TRMs).
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MRI scan of a fixed cerebral hemisphere from a person with multiple sclerosis
Neurology/Psychiatric

First GWAS for MS severity turns up first brain-related SNP

June 29, 2023
By Anette Breindl
Multiple sclerosis (MS) is and remains “a problem in the immune system” Stephen Sawcer told BioWorld. As in other autoimmune diseases, a faulty immune system attacks otherwise healthy tissues that it should be leaving alone. In the case of MS, the tissue in question is oligodendrocytes. And a study published online in Nature on June 28, 2023, suggests that while MS’ beginnings are autoimmune, the path it takes in an individual patient is determined in part by how well the brain can cope with the autoimmune attack.
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