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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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T cells
Inflammatory

ANB-033, a novel anti-human CD122 MAb for T-cell-mediated inflammatory autoimmune disorders

June 29, 2023
CD122 signaling plays a key role in the function of CD4, CD8 T cells and natural killer (NK) cells, as well as in the development and survival of tissue-resident memory T cells (TRMs).
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MRI scan of a fixed cerebral hemisphere from a person with multiple sclerosis
Neurology/Psychiatric

First GWAS for MS severity turns up first brain-related SNP

June 29, 2023
By Anette Breindl
Multiple sclerosis (MS) is and remains “a problem in the immune system” Stephen Sawcer told BioWorld. As in other autoimmune diseases, a faulty immune system attacks otherwise healthy tissues that it should be leaving alone. In the case of MS, the tissue in question is oligodendrocytes. And a study published online in Nature on June 28, 2023, suggests that while MS’ beginnings are autoimmune, the path it takes in an individual patient is determined in part by how well the brain can cope with the autoimmune attack.
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JW Pharma refiles Taiwan IND for URC-102 phase III in heated search for novel gout drug in Asia

June 28, 2023
By Marian (YoonJee) Chu
South Korea’s JW Pharmaceutical Corp. announced a redo of its IND application to the Taiwan FDA on June 27 for its phase III trial on gout treatment URC-102 (epaminurad). The second filing comes in response to a regulatory rejection in March citing a problem with the proposed reference drug.
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NLRP3 inflammasome
Inflammatory

New mitochondrial players identified in NLRP3 inflammasome activation

June 20, 2023
By Subhasree Nag
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by pathogen-associated molecular patterns (PAMPs), NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β and IL-1 that are overproduced in many inflammatory disease conditions.
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Respiratory

Intraperitoneally or orally administered OLT-1177 improves experimental allergic asthma

June 13, 2023
At the recent EAACI meeting, researchers presented preclinical data for the inflammasome inhibitor OLT-1177 (dapansutrile), which is being evaluated by Olatec Therapeutics LLC for the treatment of inflammatory diseases.
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COVID-19 research illustration
Immune

Neobiosis to advance Vixome for post-COVID syndrome

June 13, 2023
Neobiosis LLC has received FDA clearance of its IND application for Vixome for the treatment of post-COVID syndrome, or long-haul COVID...
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Inflammatory

RORα agonists described in Seoul National University patent

June 8, 2023
Research at Seoul National University has led to the identification of thiourea compounds acting as nuclear receptor RORα (RORA) agonists reported to be useful for the treatment of inflammation and metabolic diseases.
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3D illustration of the Anakinra molecular structure
Hematologic

Edited blood stem cells dampen disordered inflammation

June 8, 2023
By Anette Breindl
Researchers have ameliorated both monogenic and complex inflammation-driven diseases through transplantation of hematopoietic stem cells with an inserted IL-1 receptor antagonist (IL-1RA) gene. The team showed that in animal models the transplanted cells worked better than monoclonal antibodies to reduce symptoms in systemic autoinflammatory diseases (SAIDs), a group of childhood-onset, lifelong diseases that vary in severity depending on the underlying mutation, but can be life-threatening.
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Immune

Nontoxic corticosteroid INX-200 evaluated for severe autoimmune disease

June 7, 2023
Glucocorticoids are very effective immunosuppressive and anti-inflammatory drugs that cause dose-limiting toxicities in brain, liver and bone preventing their use mainly in chronic disorders. Researchers from Immunext Inc. recently reported results from the therapeutic evaluation of the nontoxic glucocorticoid INX-200 with anti-inflammatory efficacy in a once-per-month injection.
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3D art concept for NETosis
Inflammatory

Anti-citrullinated histone antibody CIT-013 displays anti-inflammatory properties in vivo

June 6, 2023
Neutrophil extracellular traps (NETs) are complex...
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