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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Mast cell releasing histamine during allergic response
Inflammatory

Third Harmonic Bio announces next-generation oral KIT inhibitor for inflammatory diseases

July 26, 2023
Third Harmonic Bio Inc. has announced a new product candidate, THB-335, a potent, highly selective, oral, small-molecule KIT inhibitor.
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Pill over molecule structures
Inflammatory

Recludix and Sanofi collaborate on oral STAT6 inhibitors for immunological and inflammatory diseases

July 21, 2023
Recludix Pharma Inc. has entered into a strategic collaboration with Sanofi SA to develop and commercialize first-in-class oral small-molecule STAT6 (signal transducer and activator of transcription 6) inhibitors for patients with immunological and inflammatory diseases. STAT6 is believed to play a key role in multiple dermatological and respiratory diseases.
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Handshake with DNA, molecules

Recludix enters a potential $1.2B deal with Sanofi

July 20, 2023
By Lee Landenberger
Dismissed as undruggable in the early 2000s, Src homology 2 domains are now viable and at the heart of Recludix Pharma Inc.’s new deal with Sanofi SA’s U.S. unit. The two will collaborate on developing and commercializing treatments for immunological and inflammatory diseases. In the near term, Recludix will get $125 million, but long term it could add up to $1.2 billion in milestones. Recludix could also bring in up to double-digit royalties on possible future product sales.
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Neutrophil and red blood cells
Inflammatory

Preclinical studies support further development of ADS-051, a modulator of neutrophil trafficking and activation

July 18, 2023
Recent studies suggest that neutrophils are not only involved in the innate immune response but also may play extended roles in chronic inflammatory disorders and adaptive immune responses as well.
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Lungs
Inflammatory

Neutralizing hIL-33 shows efficacy in model of acute lung inflammation

July 14, 2023
Researchers from Astrazeneca plc have presented a novel adeno-associated virus (AAV)-delivered human (h)IL-33 neutralizing scFv-based protein construct at the 2023 World Congress on Basic and Clinical Pharmacology.
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3D illustration of monocyte, lymphocyte and neutrophil surrounded by red blood cells
Musculoskeletal

Mutation of the IL-1 receptor causes autoinflammation leading to chronic recurrent multifocal osteomyelitis

July 14, 2023
A new study on the interleukin 1 (IL-1) pathway and its involvement in systemic inflammation and autoinflammatory diseases has described a mutation of the IL-1 receptor type 1 (IL-1R1) receptor associated with chronic recurrent multifocal osteomyelitis (CRMO). The variant p.Lys131Glu of this receptor was identified in a patient with CRMO. A peripheral blood mononuclear cell analysis showed an inflammatory event in lymphocytes, especially in monocytes and neutrophils. The research was conducted by a group of scientists at Zhejiang University in China and reported in the July 11, 2023, issue of Immunity.
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Heart illustration
Cardiovascular

Inflammation-resolving compound has protective effects in myocardial infarction model

July 14, 2023
The endogenous human protein annexin A1 (ANXA1) is a driver of inflammatory resolution and has shown protective effects in several models of diseases with inflammatory components, including myocardial infarction. Researchers from Resother Pharma A/S and colleagues reported on the preclinical cardioprotective role of RTP-026, a peptide derived from the ANXA1 N-terminal region that acts as N-formyl peptide receptor 2 (FPR2) ligand. In vitro, testing of receptor selectivity and activation in FPR2-HEK-293 cells showed an EC50 value between 10 and 30 nM.
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Inflammatory

Antisense targeting of NLRP3 favorably reduces inflammasome activity, increases survival in preclinical mouse model of CAPS

July 13, 2023
The nucleotide-binding and oligomerization domain-like receptor family pyrin domain...
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Lungs
Inflammatory

Novel amide compound shows anti-inflammatory activity in models of LPS-induced ALI and sepsis

July 13, 2023
Researchers from Wenzhou Medical University and affiliated organizations have reported the...
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Scientific figure illustrating astrocytes and neuron synapse
Neurology/Psychiatric

Glial cells get all-too-rare star turn at biannual meeting

July 13, 2023
By Anette Breindl
In brain research, be it basic or clinical, neurons have long hogged the limelight. But at the 2023 European Meeting on Glial Cells in Health and Disease, neurons take a back seat to glia – cell types that have often been described as support cells and treated as an afterthought, but that play critical roles in all aspects of brain function, including information processing.
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