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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Inflammation in big toe

LG Chem, JW Pharma go toe-to-toe in Asia gout drug race

Aug. 21, 2023
By Marian (YoonJee) Chu
South Korean pharmaceutical firms LG Chem Ltd. and JW Pharmaceutical Corp. are recouping and pressing on with their respective novel gout drugs internationally, with each having faced regulatory setbacks from IND rejections overseas.
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Art concept for inflamed human tissue
Inflammatory

Anti-TNF-α macrocyclic peptide with novel binding mode presented

Aug. 18, 2023
Tumor necrosis factor-α (TNF-α) is a cytokine involved in the regulation of inflammation in several autoimmune and inflammatory disorders such as rheumatoid arthritis, ulcerative colitis, or psoriasis. Anti-TNF biological treatments in place are effective but there is a need for alternatives with novel pharmacological profiles to overcome their limitations.
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Man with respiratory issues

Hengrui inks $1B out-licensing deal for asthma drug with One Bio

Aug. 17, 2023
By Marian (YoonJee) Chu
With a U.S. biotech identified as One Bio, Jiangsu Hengrui Pharmaceutical Co. Ltd. has inked an out-licensing deal potentially worth $1.05 billion for its asthma and chronic sinusitis-targeting drug, SHR-1905. The latest deal gives One Bio exclusive rights to develop, produce and commercialize SHR-1905 worldwide, excluding the greater China territory.
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AI model predicts multiple sclerosis risk from patient data

Aug. 10, 2023
By Bernard Banga
A team from Siemens Medical Solutions Inc. presented a new artificial intelligence (AI) model that can predict people’s risk of multiple sclerosis (MS), at the 2023 American Association for Clinical Chemistry (AACC) annual scientific meeting in Anaheim, Calif.
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Mast cell
Inflammatory

First clinical candidate nominated from Peptidream and Modulus strategic partnership

Aug. 4, 2023
Peptidream Inc. and Modulus Discovery Inc. have nominated the first clinical development candidate arising from the companies’ strategic drug discovery partnership.
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Inflammatory

Innate immune pathway has role in age-related cognitive decline

Aug. 2, 2023
By Anette Breindl
Swiss researchers have gained new insights into the relationship between aging, inflammation, neurodegeneration and cognitive decline. EPFL professor Andrea Ablasser and her team showed that brain aging was driven by microglial activation of the cGAS/STING pathway.
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Lungs wireframe illustration

Developers selectin’ galectin across range of indications

July 31, 2023
By Randy Osborne
The notion of taking aim at the galectin pathway across varied therapeutic areas has gained major traction in recent years, with a handful of companies drawing Wall Street’s interest as efforts plow forth in conditions as varied as cancer, liver fibrosis and Alzheimer’s disease.
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Inflammatory

Haisco Pharmaceutical divulges LPAM-1 antagonists for inflammatory disorders

July 31, 2023
Haisco Pharmaceutical Group Co. Ltd. has described propionic acid derivatives acting as integrin α4β7 (LPAM-1) antagonists reported to be useful for the treatment of inflammatory disorders.
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Illustration of cancer cells entering the bloodstream.
Immuno-oncology

Novel anti-ChemR23 agonist MAb reprograms macrophages and limits metastasis in vivo

July 31, 2023
Researchers from OSE Immunotherapeutics SA have published preclinical data for the novel anti-ChemR23 monoclonal antibody (MAb) (OSE-230) with anti-inflammatory properties, being evaluated for the potential treatment of cancer.
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Mast cell releasing histamine during allergic response
Inflammatory

Third Harmonic Bio announces next-generation oral KIT inhibitor for inflammatory diseases

July 26, 2023
Third Harmonic Bio Inc. has announced a new product candidate, THB-335, a potent, highly selective, oral, small-molecule KIT inhibitor.
Read More
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