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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Hands illustrating pain and inflammation
Neurology/Psychiatric

New nicotinic receptor ligands may be helpful to reduce inflammatory pain through the CAS

Dec. 28, 2023
Novel non-addicting analgetic therapies are urgently needed to reduce the use of opiates as painkillers. With the recent discovery that nicotinic acetylcholine receptors (nAChRs) in the immune system can be stimulated to decrease the release of pro-inflammatory cytokines, the cholinergic anti-inflammatory systems (CAS) have generated significant interest in treating pain associated with inflammation.
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Test tubes, dropper
Drug Design, Drug Delivery & Technologies

Matinas reports findings from in vivo studies of oral LNC-delivered small oligonucleotides

Dec. 28, 2023
Matinas Biopharma Holdings Inc. has reported results from a series of in vivo studies demonstrating successful oral delivery of two lipid nanocrystal (LNC)-formulated small single-strand oligonucleotides that specifically target the key inflammatory cytokines TNF-α and IL-17A in well-established and validated animal models that mimic acute inflammatory responses seen in human diseases.
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Inflammatory

Sudo Biosciences presents new TYK2 inhibitors

Dec. 22, 2023
Sudo Biosciences Ltd. has divulged non-receptor tyrosine-protein kinase TYK2 (JH2 domain) inhibitors reported to be useful for the treatment of inflammation and autoimmune disease.
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Caliway raises $100M for late-stage subcutaneous fat reducing drug

Dec. 19, 2023
By Marian (YoonJee) Chu
Taiwan’s Caliway Biopharmaceuticals Co. Ltd. said it secured more than $100 million in an oversubscribed capital raise to advance CBL-514, its lead asset for subcutaneous fat reduction nearing phase III studies.
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Caliway raises $100M for late-stage subcutaneous fat reducing drug

Dec. 18, 2023
By Marian (YoonJee) Chu
Taiwan’s Caliway Biopharmaceuticals Co. Ltd. said it secured more than $100 million in an oversubscribed capital raise to advance CBL-514, its lead asset for subcutaneous fat reduction nearing phase III studies.
Read More
Endocrine/Metabolic

Deep Apple raises series A to accelerate drug discovery

Dec. 15, 2023
Deep Apple Therapeutics Inc., a portfolio company created and incubated by Apple Tree Partners, has raised $52 million in series A round.
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Antibodies and red blood cells
Dermatologic

Teva licenses rights to Biolojic's BD9 for atopic dermatitis and asthma

Dec. 15, 2023
Teva Pharmaceutical Industries Ltd. and Biolojic Design Ltd. have announced an exclusive license agreement to develop a potential novel antibody-based therapy for the treatment of atopic dermatitis and asthma.
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Inflammatory

New PDE4 inhibitors are active against neutrophilic inflammation

Dec. 15, 2023
Researchers from National Cheng Kung University and affiliated organizations have presented the discovery and preclinical evaluation of novel pyrazole derivatives that inhibit the neutrophil signaling pathway, to be developed for the treatment of inflammation.
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Illustration of leg anatomy with target around knee
Newco news

Another go at NGF as Levicept targets chronic pain due to osteoarthritis

Dec. 13, 2023
By Nuala Moran
Just over a year since the last anti-nerve growth factor (NGF) antibody program was axed, the target is poised for a revival, with Levicept Ltd. announcing it has completed recruitment to a phase II trial of LEVI-04 in the control of chronic pain caused by osteoarthritis.
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acoustic wave therapy
Patents

Acoustic wave therapy device for treating rheumatoid arthritis

Dec. 13, 2023
By Simon Kerton
Researchers from Stanford University seek patent protection for an ultrasound-based device which converts electrical energy into acoustic energy to treat inflammatory disorders. The neuromodulator device targets the cholinergic anti-inflammatory pathway (CAP), which regulates the innate immune response to injury, pathogens, and tissue ischemia.
Read More
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