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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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3D illustration of a ribosome constructing messenger RNA molecules
Inflammatory

Immetas and GC Biopharma collaborate on mRNA therapeutics for autoimmune diseases

Oct. 13, 2023
Immetas Therapeutics Inc. and GC Biopharma Corp. have entered into a research collaboration to discover and develop novel mRNA therapeutics for the treatment of a broad range of autoimmune diseases. The collaboration combines Immetas’ proprietary platform for modulating innate immune pathways with GC Biopharma’s mRNA therapeutic and lipid nanoparticle (LNP) delivery platforms.
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Close up of senior man holding wrist of arthritic hand
Inflammatory

Imidomics signs agreement with University of Barcelona to advance research in immune-mediated inflammatory diseases

Oct. 13, 2023
Imidomics Inc. has entered into a strategic license and collaboration agreement with the University of Barcelona under which Imidomics has licensed technology and expertise to advance research aimed at understanding and treating immune-mediated inflammatory diseases.
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Test tubes, dropper and capsules
Inflammatory

Targeting of the heteromeric GPCR CXCR4:LPA1 complex appears promising in the context of cancer and fibrosis

Oct. 13, 2023
Researchers working at with Seoul National University together with GPCR Therapeutics Inc. have focused on targeting pairs of G protein-coupled receptors (GPCRs) starting with the CXC chemokine receptor 4 (CXCR4), which is well known to serve hematopoietic and early developmental functions, while also being required for cancer metastasis.
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AI generated illustration of a brain on fire
Neurology/Psychiatric

ECNP 2023: Look for antibodies in idiopathic psychoses? First, maybe better tests

Oct. 10, 2023
By Anette Breindl
For individuals who develop an unexpected psychosis, there is something to be said for testing them for autoimmune antibodies. And something against. At the 36th Congress of the European College of Neuropsychopharmacology (ECNP) this week, the topic was worth a controversy session, where speakers presented the pros and cons of the approach. Currently used tests have a specificity of 99%. But as Ester Coutinho, consultant neurologist at the University of Coimbra, pointed out, the validity of diagnostic tests depends on the prevalence of the disorder one is looking for as well. Coutinho estimated that autoimmune psychoses account for 1% of psychoses overall.
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Red blood cells and coronavirus
Infection

Human blood vessels transplanted in mice reveal COVID-19 coagulation molecule

Oct. 6, 2023
By Subhasree Nag
Recently, researchers at Cincinnati Children’s Hospital, in collaboration with colleagues in Japan, have developed a human vascular organoid model that accurately mimics the vascular damage caused by SARS-CoV-2.
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Elderly hands holding broken brain structure
Neurology/Psychiatric

Omics studies reveal 'Google map' of Alzheimer’s disease

Oct. 5, 2023
By Mar de Miguel
The broadest view of post-mortem brains in Alzheimer’s disease (AD) has unveiled the genome, transcriptome and epigenome alterations of this neurodegenerative condition. The coordinated research, directed by scientists at the Massachusetts Institute of Technology (MIT), also described new cellular pathways that could help the scientific community design new therapies. Four simultaneous studies published on Sept. 28, 2023, in Cell, presented a brain single-cell atlas of AD, exposed the damage that affects DNA, and described the processes that alter the microglia and dysregulate the epigenome.
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Elderly hands holding broken brain structure
Neurology/Psychiatric

Omics studies reveal 'Google map' of Alzheimer’s disease

Oct. 5, 2023
By Mar de Miguel
The broadest view of post-mortem brains in Alzheimer’s disease (AD) has unveiled the genome, transcriptome and epigenome alterations of this neurodegenerative condition. The coordinated research, directed by scientists at the Massachusetts Institute of Technology (MIT), also described new cellular pathways that could help the scientific community design new therapies. Four simultaneous studies published on Sept. 28, 2023, in Cell, presented a brain single-cell atlas of AD, exposed the damage that affects DNA, and described the processes that alter the microglia and dysregulate the epigenome.
Read More
Inflammatory

Shanghai Zhigen Pharmaceutical presents new non-receptor tyrosine-protein kinase TYK2 inhibitors

Oct. 4, 2023
Shanghai Zhigen Pharmaceutical Technology Co Ltd. has divulged nonreceptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of inflammation and autoimmune diseases.
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Drug R&D concept image.
Inflammatory

Atomwise nominates TYK2 inhibitor development candidate

Oct. 4, 2023
Atomwise Inc. has nominated a development candidate focused on TYK2 inhibition, discovered by leveraging its proprietary artificial intelligence (AI) drug discovery platform, Atomnet.
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Lab research with pipette, microsope
Inflammatory

Discovery of new anti-inflammatory PROTACs acting through BTK degradation

Oct. 3, 2023
Bruton tyrosine kinase (BTK) inhibition is a provenly effective strategy for the treatment of B-cell malignancies with several compounds approved such as ibrutinib, acalabrutinib or zanubrutinib. BTK also plays a central role in immunity and has thus emerged as a potential therapeutic target in autoimmune and inflammatory disorders.
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