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BioWorld - Monday, May 23, 2022
Home » Topics » Ocular, BioWorld

Ocular, BioWorld
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Kriya lands $270M series C as it hones gene therapy pipeline

May 16, 2022
By Lee Landenberger
No Comments
Kriya Therapeutics Inc. has raised a $270 million series C financing to further develop its pipeline of gene therapies for treating cancer, ophthalmological problems, and rare and chronic diseases. The Redwood City, Calif.-based company has greatly expanded its employee roster, from about seven people to around 160 people, since its $80 million series A in May 2020 and scaled its learning-enabled tech and cloud computing abilities. It also further solidified its technology, manufacturing, R&D, and therapeutics units, something it plans to continue with the series C money.
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Eye wireframe illustration
Newco news

Vigeneron carves out space in evolving AAV gene therapy landscape

May 13, 2022
By Cormac Sheridan
No Comments
Although gene therapy is now “a clinical reality,” it still remains an early stage therapeutic modality. That’s the view of Caroline Man Xu, CEO and co-founder of Vigeneron GmbH, a German gene therapy company that has maintained a low profile while steadily staking out a promising position in gene therapies for inherited retinal disease.
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Eye exam

Zhaoke licenses Asian rights to Visus presbyopia candidates in $130M deal

May 13, 2022
By Tamra Sami
No Comments
Visus Therapeutics Inc. has out-licensed phase III candidates Brimochol and Carbachol to Hong Kong’s Zhaoke Ophthalmology Ltd. to develop and commercialize its long-acting, presbyopia-correcting eye drops in greater China, South Korea and select Southeast Asian territories.
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Antibodies attacking cancer cell

Askgene’s series A adds $20M for cytokine fusion, antibody pipeline

May 9, 2022
By Jennifer Boggs
No Comments
Askgene Pharma Inc., which less than two weeks ago reported positive initial data from an ongoing phase I/II trial testing its claudin 18.2-targeting candidate, ASKB-589, added $20 million in a series A round, intended to advance the company’s clinical pipeline and support further development of its Smartkine cytokine drug platform.
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Oxurion shares fall 40% on phase II miss in DME

May 9, 2022
By Cormac Sheridan
No Comments
Shares in Oxurion NV dropped 40.3% percent May 9 on news that one of its two clinical-stage assets, THR-687, failed to demonstrate efficacy in a phase II trial in diabetic macular edema (DME). The candidate, a small-molecule pan integrin receptor antagonist, failed to demonstrate efficacy in Part A of the trial, called Integral, in which treatment-naïve patients received one of two doses of THR-687.
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IPO money

Pepgen and B&L join a struggling IPO market

May 6, 2022
By Lee Landenberger
No Comments
IPOs continue to be sluggish but two companies, Pepgen Inc. and Bausch & Lomb Corp., that began trading May 6 managed to sidestep the turbulence despite having to lower their expectations before the market opened. Pepgen stock (NASDAQ:PEPG) closed at $12.89 per share May 6, up 7.4% on the day. Bausch & Lomb also had a solid IPO launch May 6 as shares (NYSE:BLCO) closed 11.1% upward at $20 each.
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Gold dollar sign

Ashvattha lands $69M series B, Huadong licensing deal

April 27, 2022
By David Ho
No Comments
Ashvattha Therapeutics Inc. secured $69 million in a series B financing that it said will strengthen its ability to develop hydroxyl dendrimer-based medicines and accelerate efforts to advance its candidates to the clinic.
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The eyes have it: Orasis has an NDA in its sights for presbyopia

April 21, 2022
By Lee Landenberger
No Comments
Privately held Orasis Pharmaceuticals Ltd. is a step closer to challenging Abbvie Inc.’s Vuity (pilocarpine hydrochloride) ophthalmic solution for treating presbyopia, a version of farsightedness. Orasis plans to submit an NDA to the U.S. FDA in the second half of the year based on phase III results from two studies showing CSF-1 hit its primary and secondary endpoints.
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Eye wireframe illustration
Newco news

‘Endo’ the line for CESED? Aurion cell therapy raises $120M

April 14, 2022
By Randy Osborne
No Comments
Aurion Biotech Inc. pulled down a $120 million financing to advance efforts with its lead candidate, a cell therapy for the treatment of corneal edema secondary to endothelial dysfunction (CESED).
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Ji Xing wins greater China rights to Lenz’s presbyopia drugs in $110M deal

April 14, 2022
By Doris Yu
No Comments
Ji Xing Pharmaceuticals Ltd. has acquired greater China rights to two candidates from Lenz Therapeutics Inc. for the treatment of presbyopia in greater China in a deal worth up to $110 million. San Diego-based Lenz will receive $15 million in up-front payments, up to $95 million in regulatory and commercial milestone payments, and potential royalty payments based on net sales.
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