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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
Respiratory RSS Feed RSS

Pill over molecule structures
Inflammatory

Recludix and Sanofi collaborate on oral STAT6 inhibitors for immunological and inflammatory diseases

July 21, 2023
Recludix Pharma Inc. has entered into a strategic collaboration with Sanofi SA to develop and commercialize first-in-class oral small-molecule STAT6 (signal transducer and activator of transcription 6) inhibitors for patients with immunological and inflammatory diseases. STAT6 is believed to play a key role in multiple dermatological and respiratory diseases.
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Lungs and bronchi

Insilico progresses AI-discovered drug to phase II trials in idiopathic pulmonary fibrosis

July 20, 2023
By Tamra Sami
Artificial intelligence (AI) drug discovery specialist Insilico Medicine Inc. is progressing INS018-055, its lead compound to phase II trials for idiopathic pulmonary fibrosis, a chronic lung disease that results in progressive and irreversible decline in lung function.
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Lungs
Newco news

Glycocore seeking €10M to advance Hylach technology

July 17, 2023
By Nuala Moran
Newco Glycocore Pharma Srl is setting out to raise €10 million (US$11.2 million) in a series A round to take a novel approach to treating inflammatory respiratory diseases into the clinic, starting with a phase I/Ib trial in idiopathic pulmonary fibrosis.
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Respiratory

Rho kinase inhibitors described in Chiesi Farmaceutici patent

July 17, 2023
Chiesi Farmaceutici SpA has identified dihydrofuropyridine derivatives acting as Rho kinase 1 (ROCK1; p160-ROCK) and/or Rho kinase 2 (ROCK2; ROCKα) inhibitors.
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IPO window swings open for Apogee and Sagimet

July 14, 2023
By Karen Carey
Two biopharma companies entered the public markets on July 14, with Apogee Therapeutics Inc. pricing a $300 million IPO, the second largest U.S. debut this year, and Sagimet Biosciences Inc. raising $85 million. Apogee, of San Francisco, and Waltham, Mass., is advancing APG-777 and APG-808, which are in development for atopic dermatitis (AD) and chronic obstructive pulmonary disease, while San Mateo, Calif.-based Sagimet’s lead candidate is the FASN inhibitor denifanstat for nonalcoholic steatohepatitis.
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Lungs
Inflammatory

Neutralizing hIL-33 shows efficacy in model of acute lung inflammation

July 14, 2023
Researchers from Astrazeneca plc have presented a novel adeno-associated virus (AAV)-delivered human (h)IL-33 neutralizing scFv-based protein construct at the 2023 World Congress on Basic and Clinical Pharmacology.
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Surf’s not up? First Wave phase II ‘likely’ missed efficacy endpoint

July 13, 2023
By Lee Landenberger
First Wave Biopharma Inc. is taking apart the top-line data from its phase II study of adrulipase for treating nutrition deficiencies in cystic fibrosis patients and seems unsure exactly what it found. The company said that while the initial data found the enhanced enteric microgranule delivery formulation of adrulipase was safe, well-tolerated and was an improvement over other formulations, the preliminary data also indicate that “it is likely the primary efficacy endpoint was not achieved.”
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Respiratory

Sato Pharmaceutical presents new HPGDS inhibitors

July 13, 2023
Sato Pharmaceutical Co. Ltd. has divulged azaindole derivatives acting as hematopoietic prostaglandin D synthase (HPGDS) inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, myocardial infarction, rheumatoid arthritis, sarcopenia and thromboangiitis obliterans (Buerger’s disease), among others.
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Sleep apnea illustration

Resmed buying respiratory diagnostics software company Somnoware

July 7, 2023
By Meg Bryant
Resmed Inc. has acquired Somnoware Inc., a privately held developer of respiratory care diagnostics software, for an undisclosed price. The deal is Resmed’s third software acquisition in the past year, having snapped up German software-as-a-service (SaaS) maker Medifox Dan GmbH for $1 billion in June 2022 and Mementor GmbH last August.
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Respiratory

Yingxi Intelligent Technology divulges new FGFR inhibitors

July 7, 2023
Yingxi Intelligent Technology (Shanghai) Co. Ltd. has identified substituted monocyclic or bicyclic heterocyclic compounds acting as fibroblast growth factor receptor (FGFR) inhibitors and reported to be useful for the treatment of asthma, cancer, chronic heart failure, chronic obstructive pulmonary disease, rheumatoid arthritis, inflammation, autoimmune and Parkinson’s disease, among others.
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