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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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Lungs
Respiratory

MCEMP1, a KIT receptor adaptor promoting mast cell proliferation in chronic airway inflammation

April 28, 2023
Mast cell-expressed membrane protein 1 (MCEMP1) is a type II transmembrane protein predominantly expressed in myeloid lineage immune cells, including lung-resident mast cells and alveolar macrophages. MCEMP1 is a critical factor in allergic and inflammatory lung diseases, with higher expression levels correlating with increased disease severity. However, the molecular mechanisms underlying the role of MCEMP1 in the pathogenesis of lung inflammatory diseases remain unclear.
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Respiratory

Chiesi Farmaceutici divulges new TGFBR1 inhibitors for IPF

April 21, 2023
Chiesi Farmaceutici SpA has synthesized pyridazinyl amino derivatives acting as TGF-β receptor type-1 (TGFBR1; ALK5; SKR4; TβR-I) inhibitors reported for be useful for the treatment of idiopathic pulmonary fibrosis (IPF).
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Lungs
Respiratory

Grant supports Senisca’s development of oligonucleotide therapeutics for IPF

April 20, 2023
Senisca Ltd. has been awarded a £571,350 (US$712,000) grant from Innovate UK toward the development of oligonucleotide therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF).
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Lungs
Respiratory

Vyne’s pan-BET inhibitor VYN-201 shows promise in mouse model of IPF

April 20, 2023
Vyne Therapeutics Inc. has released new...
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GSK House London

Bellus’ stock surges as GSK coughs up $2B for an acquisition

April 18, 2023
By Lee Landenberger
In its $2 billion acquisition of Bellus Health Inc., GSK plc is getting camlipixant, which is being developed to treat refractory chronic cough. The selective P2X3 receptor antagonist is currently in phase I and phase III studies. Bellus will be acquired by GSK for $14.75 per share in cash.
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Aer Therapeutics’ $36M series A propels mucus-busting AER-01 to clinic for COPD

April 13, 2023
By Karen Carey
With no treatments available to effectively clear mucus, Aer Therapeutics Inc. secured $36 million in a series A financing to advance its novel inhaled small-molecule mucolytic treatment, AER-01, bringing optimism to about 5 million Americans with chronic obstructive pulmonary disease (COPD) who have a high burden of mucus plugs.
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Respiratory

Ocean Biomedical to develop OCF-203 for pulmonary fibrosis in Hermansky-Pudlak syndrome

April 11, 2023
Ocean Biomedical Inc. announced it will be targeting its pulmonary fibrosis treatment candidate OCF-203 as a novel therapeutic for fatal pulmonary fibrotic conditions caused by Hermansky-Pudlak syndrome (HPS).
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Lungs
Respiratory

Boehringer Ingelheim discloses discovery and structure of PDE4 inhibitor BI-1015550

April 6, 2023
Boehringer Ingelheim Pharma GmbH & Co...
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Respiratory

AGC Biologics signs agreement with The Jikei University in field of IPF

April 4, 2023
AGC Biologics Inc. has signed a service agreement with The Jikei University for a drug product...
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Respiratory

Genzyme patents CFTR modulators for treatment of cystic fibrosis

March 30, 2023
Recent Genzyme Corp. patents describe indole compounds acting as cystic fibrosis...
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