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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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Respiratory

Intraperitoneally or orally administered OLT-1177 improves experimental allergic asthma

June 13, 2023
At the recent EAACI meeting, researchers presented preclinical data for the inflammasome inhibitor OLT-1177 (dapansutrile), which is being evaluated by Olatec Therapeutics LLC for the treatment of inflammatory diseases.
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Biosency Bora platform

Biosency detects COPD exacerbations early thanks to predictive digital medical device

June 12, 2023
By Bernard Banga
Biosency SAS recently unveiled the latest results on its predictive digital medical device for remote monitoring of patient suffering from chronic obstructive pulmonary disease (COPD). The Bora platform demonstrated its ability to predict COPD exacerbation on average three days prior to hospitalization.
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Lung illustration
Respiratory

Cell atlas maps out lung in health and disease

June 12, 2023
By Nuala Moran
Another brick in the ambitious Human Cell Atlas initiative has been put into place with the publication of the largest and most comprehensive cell map of the human lung. The open and freely available atlas catalogs the diversity of cells in the lung, including rare and previously undescribed cell types.
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Lungs

Vicore Pharma raises $46M to fund phase IIb trial in IPF

June 9, 2023
By Cormac Sheridan
Vicore Pharma Holding AB grossed about SEK500 million (US$46 million) in a directed share issue that will fund a phase IIb trial of its lead drug candidate, C-21, in idiopathic pulmonary fibrosis (IPF).
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Moving Upstream with $200M series B and TSLP-targeting asthma drug

June 8, 2023
By Karen Carey
Less than two years ago, in October 2021, a group of investors bid at auction on a promising monoclonal antibody to treat asthma, chronic rhinosinusitis and other inflammatory conditions, winning the asset known as UPB-101, the sole focus of the then-newly launched Upstream Bio Inc.
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Pseudomonas aeruginosa
Infection

Antibody targeting of multiple P. aeruginosa evasion mechanisms enhances neutrophil-mediated phagocytosis and killing efficacy

June 8, 2023
Bronchiectasis is an irreversible chronic respiratory condition arising from secondary infections that presents as chronic cough with daily purulent sputum due to a permanent abnormal widening of bronchi.
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Heart and lungs
Respiratory

ANPA-0073 and ANPA-0137, G protein-biased APJ agonists with efficacy in models of IPF and PAH

June 8, 2023
Researchers from Structure Therapeutics Inc. recently presented details on the discovery and preclinical evaluation of two new apelin receptor (APJ, APLNR) agonists – ANPA-0073 and ANPA-0137 – being developed for the treatment of pulmonary diseases.
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Drug R&D concept image.
Gastrointestinal

Liminal Biosciences announces preclinical pipeline progress

June 6, 2023
Liminal Biosciences Inc. has nominated a lead preclinical candidate, LMNL-6326, from its oxoeicosanoid receptor 1 (OXER1) antagonist program, targeting the treatment of eosinophil-driven diseases such as eosinophilic asthma and atopic dermatitis.
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Lungs
Respiratory

ROCK2 inhibitor GNS-3595 reduces IPF progression in preclinical models

June 2, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic...
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Cancer

Macrophage senescence promotes lung cancer progression

June 2, 2023
By Mar de Miguel
With age, senescent cells become detrimental to tissues. Mayo Clinic scientists have observed this phenomenon in the lung alveoli, where senescent macrophages accumulated in aging tissue and in early stages of non-small-cell lung cancer (NSCLC) driven by the Kras oncogene. “We found that the macrophages were present in the earliest stages of the disease. Strategies targeting these cells for elimination or preventing their accumulation would be worthwhile to test in other conditions (assuming we find they occur),” Darren Baker, a Mayo Clinic senescent cell biologist and senior author of the study, told BioWorld.
Read More
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