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Home » Topics » Disease categories and therapies » Urology

Urology
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3D illustration showing tumor inside prostate gland and closeup view of cancer cells
Cancer

Androgen receptor, PSMA are not in lockstep in prostate cancer

April 12, 2023
By Mar de Miguel
As prostate cancer progresses, tumors lose the androgen receptor (AR) on which initial treatment is based. Oftentimes, such patients also lose expression prostate-specific membrane antigen (PSMA), which is the target of approved agent Pluvicto (lutetium (177Lu) vipivotide tetraxetan; Novartis AG) as well as a number of experimental drugs. Such patients can no longer benefit from either androgen- or PSMA-directed therapy.
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Olive seeking $10M in A round for urine analysis system

Dec. 12, 2022
By Nuala Moran
Olive Diagnostics Pvt. Ltd. is looking to raise $10 million in a series A funding round to extend sales and marketing activities, after getting CE approval for its urine analysis device that mounts on any toilet. Among other parameters the device, Olive KG, can measure red blood cells, proteins, nitrates, pH levels volume, pressure and frequency of urination.
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Genitourinary/Sexual Function

LIB-01 for erectile dysfunction shows promising safety profile in preclinical toxicology studies

Oct. 13, 2022
Dicot AB reports that LIB-01 has shown a...
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Cancer

Cyclin K could be biomarker for PARP inhibitor sensitivity in mCRPC

Sep. 28, 2022
By Mar de Miguel
A Mayo Clinic study demonstrated how the deficiency of the enzyme CDK12 or its regulation by cyclin K causes the expression of mutations related to resistance to endocrine therapy in prostate cancer. Prostate tumors with CDK12 deficiency are more aggressive, recurrent, produce metastases and are associated with castration-resistant prostate cancer (CRPC). CDK12 deficiency impairs DNA repair and increases genomic instability, causing an effect known as homologous recombination deficiency or BRCAness.
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Abstract molecules illustration
Urology

Kashiv Biosciences describes new compounds for interstitial cystitis and pain

Sep. 19, 2022
Kashiv Biosciences LLC has synthesized prodrugs of azo compounds reported to be useful for the treatment of interstitial cystitis and pain, among other disorders.
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CFB inhibitors identified by Shanghai Hengrui Pharmaceutical, Jiangsu Hengrui Medicine

July 27, 2022

Ketamine-inspired compound shows efficacy in rat model of renal I/R injury

July 25, 2022
Illustration if kidney organs, kidney stones

Calyxo garners $32.7M for kidney stone treatment

July 8, 2022
By Annette Boyle
Calyxo Inc. cleaned up with a $32.7 million series C financing round to support further development of the Cvac system for kidney stones. Questa Capital and CRG led the round, which brought the company’s total funds raised to $47.2 million.
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Oral and topical CF-602 significantly reduces erectile dysfunction in vivo

July 8, 2022

AstraZeneca, Mitsubishi Tanabe Pharma present new relaxin receptor 1 agonists

July 7, 2022
Previous 1 2 3 4 5 6 7 8 9 10 11 … 316 317 Next

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