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BioWorld - Saturday, June 14, 2025
Home » Topics » Immuno-oncology, BioWorld Science

Immuno-oncology, BioWorld Science
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Oncolytic virus concept illustration
Immuno-oncology

Dual, tumor-specific TNFR2 and CD47 blockade using an oncolytic virus enhances anticancer immunity

June 13, 2025
No Comments
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide. Recent advancements in immunotherapy have demonstrated the potential of targeting immune checkpoints and co-inhibitory pathways to enhance antitumor responses.
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Immuno-oncology

CD97-targeting CAR T cells with enhanced persistence show promise in AML xenograft models

June 13, 2025
No Comments
Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by the accumulation of immature myeloid cells. Current treatments often fail to achieve durable remission, underscoring the need for innovative therapeutic approaches. CD97 is a cell surface protein with broad, increased expression on AML cells compared to normal blood stem and progenitor cells. Moreover, CD97 overexpression in AML patients has been associated with poor survival, thus emerging as a potential therapeutic target.
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Cancer

Oncolytic adenovirus aids in overcoming immunotherapy resistance in PDAC

June 11, 2025
No Comments
Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer characterized by very poor prognosis and resistance to immunotherapy due to an immunosuppressive tumor microenvironment, which includes extensive desmoplasia and a dense stroma.
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Concept art for targeting cancer
Immuno-oncology

AMED funding supports Rakuten’s photoimmunotherapy for malignant epithelial tumors

June 5, 2025
No Comments
Rakuten Medical Inc.’s RM-0256 has been selected for funding by Japan’s Agency for Medical Research and Development (AMED).
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Mesothelioma
Immuno-oncology

Oncovita’s Mvdeltac designated orphan drug for pleural mesothelioma

June 5, 2025
No Comments
Oncovita SAS’s lead oncolytic virus candidate, Mvdeltac, has been awarded orphan drug designation by the FDA.
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Cancer cell destruction by nanoparticles
Immuno-oncology

Cancervax advances cancer program with creation of cell-targeting nanoparticle

June 5, 2025
No Comments
Cancervax Inc. has successfully created a nanoparticle that can target specific cells that are potentially cancerous.
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Handshake with globe background and digital overlay
Immuno-oncology

Epimab sells bispecific T-cell engager to Juri in $210M deal

June 4, 2025
By Marian (YoonJee) Chu
No Comments
Epimab Biotherapeutics Inc. licensed out a development-ready KLK2/CD3 bispecific T-cell engager (TCE) for advanced prostate cancer to Juri Biosciences Inc. through a potential $210 million deal.
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Test tube, dropper, DNA illustration
Immuno-oncology

THNB-3 therapeutic shows promise in LIN28-positive tumors

June 3, 2025
No Comments
LIN28 is a family of RNA-binding proteins that regulate stem cell biology and pluripotency and are involved in oncogenesis through the interaction with tumor suppressor microRNA let-7. The expression of LIN28 leads to the loss of function of let-7, leading to tumorigenesis, and has been tied to tumor aggressiveness and poor survival in children with brain tumors.
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Immuno-oncology

Potentiating interferon-α immunotherapy against hepatocellular carcinoma

June 2, 2025
No Comments
Interferon (IFN)-α, on paper, should be quite effective against hepatocellular carcinoma, the most frequent form of primary liver cancer. IFN-α can suppress tumor growth directly by acting on tumor cells, as well as indirectly by activating cytotoxic CD8+ T cells. In addition, it can slow replication of hepatitis B virus, which is involved in 50% to 80% of cases of hepatocellular carcinoma. However, IFN-α on its own has performed disappointingly in clinical trials.
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3D illustration of tumor
Immuno-oncology

Proof of concept demonstrated for Voltron’s VTX-0P4 in PSCA-expressing tumors

May 30, 2025
No Comments
Voltron Therapeutics Inc. has reported data from a study evaluating VTX-0P4.
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