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BioWorld - Friday, December 5, 2025
Home » Topics » Drugs » Protein

Protein
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After axing 95% workforce, Vor bets $4B+ on Remegen’s telitacicept

June 26, 2025
By Marian (YoonJee) Chu
No Comments
Just a month after laying off 147 employees and announcing plans to mull “strategic alternatives,” Vor Biopharma Inc. reported raising $175 million in private placement in public equity financing and inking a new $4.23 billion license deal for Yantai Rongchang Biotechnologies (Remegen) Co. Ltd.’s telitacicept, a dual-target fusion protein drug approved in China for three autoimmune indications. The news was disclosed after U.S. market hours June 25. Vor’s shares (NASDAQ:VOR) gained 34 cents, or 60.5%, to close June 26 at 89 cents. The company’s shares had risen for eight consecutive trading days since June 17.
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T cells
Immune

Cue Biopharma holds pre-IND meeting with FDA for lead autoimmune asset

June 25, 2025
No Comments
Cue Biopharma Inc. has received pre-IND feedback from the FDA to discuss the proposed development plan for CUE-401, its lead autoimmune asset. Based on FDA feedback, the company intends to file an IND pending completion of final IND-enabling studies.
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Abion strikes $1.3B antibody drug deal with unidentified partner

June 25, 2025
By Marian (YoonJee) Chu
No Comments
Abion Inc. signed a potential $1.315 billion deal with an anonymous partner June 22, granting the counterparty exclusive global rights to a preclinical claudin 3-targeting monoclonal antibody, ABN-501, and the potential to license four more protein targeting antibodies.
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Nektar juiced by rezpeg atopic dermatitis phase IIb data

June 24, 2025
By Randy Osborne
No Comments
Atopic dermatitis data from Nektar Therapeutics Inc. put investors even more in the mood for further results with rezpegaldesleukin (rezpeg), an IL-2 pathway agonist and regulatory T-cell proliferator, also in the works for severe to very severe alopecia areata.
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Signify Daniel-Siegwart and RA Session II
Drug design, drug delivery & technologies

Signify Bio’s $15M round advances in situ protein therapeutics

June 6, 2025
By Karen Carey
No Comments
Turning the human body into a biofactory of precision protein therapeutics is the focus of newly launched Signify Bio, which emerged with an oversubscribed $15 million initial financing to advance three platforms with broad potential across therapeutic areas.
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Signify Daniel-Siegwart and RA Session II
Newco news

Signify Bio’s $15M round advances in situ protein therapeutics

June 5, 2025
By Karen Carey
No Comments
Turning the human body into a biofactory of precision protein therapeutics is the focus of newly launched Signify Bio, which emerged with an oversubscribed $15 million initial financing to advance three platforms with broad potential across therapeutic areas.
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China clears Mabwell’s Mailisheng injection to treat neutropenia

June 3, 2025
By Marian (YoonJee) Chu
No Comments
Mabwell (Shanghai) Bioscience Co. Ltd. on May 30 gained Chinese approval of Mailisheng (albipagrastim alfa; 8MW-0511) as a subcutaneous injection to treat febrile neutropenia induced by myelosuppressive anticancer treatment, such as radiotherapy and chemotherapy.
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Next IgAN contenders line up; Vera preps a BLA for atacicept

June 3, 2025
By Karen Carey
No Comments
With a 42% placebo-adjusted reduction in proteinuria at week 36, Vera Therapeutics Inc. met its primary endpoint in the Origin phase III trial with BAFF and APRIL dual inhibitor atacicept in treating immunoglobulin A nephropathy (IgAN) in adults.
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China clears Mabwell’s Mailisheng injection to treat neutropenia

June 2, 2025
By Marian (YoonJee) Chu
No Comments
Mabwell (Shanghai) Bioscience Co. Ltd. on May 30 gained Chinese approval of Mailisheng (albipagrastim alfa; 8MW-0511) as a subcutaneous injection to treat febrile neutropenia induced by myelosuppressive anticancer treatment, such as radiotherapy and chemotherapy.
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3D illustration of tumor
Immuno-oncology

Proof of concept demonstrated for Voltron’s VTX-0P4 in PSCA-expressing tumors

May 30, 2025
No Comments
Voltron Therapeutics Inc. has reported data from a study evaluating VTX-0P4.
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