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BioWorld - Thursday, April 16, 2026
Home » Topics » Drugs » Small molecule

Small molecule
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Chromosomes (purple) being pulled apart during cell division.
Cancer

Imidazo[1,2-a]pyridine-based antitumor tubulin inhibitors

Feb. 10, 2026
No Comments
Hubei Polytechnic University (Huangshi, China) scientists and collaborators aimed to develop potential tubulin polymerization inhibitors that may also synergize with immunotherapies for cancer treatment.
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Iambic raises the bard in AI, pens $1.7B Takeda deal

Feb. 9, 2026
By Randy Osborne
No Comments
Iambic Therapeutics Inc.’s multiyear technology and discovery pact with Takeda Pharmaceutical Co. Ltd. could help the San Diego-based firm advance its own pipeline in a big way.
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Priovant’s brepo impresses in phase II cutaneous sarcoidosis trial

Feb. 6, 2026
By Jennifer Boggs
No Comments
On the heels of an NDA submission for brepocitinib in dermatomyositis, Priovant Therapeutics Inc. disclosed data showing the dual TYK2/JAK1 inhibitor surpassed expectations in a phase II study in cutaneous sarcoidosis, another chronic inflammatory skin condition with limited treatment options, setting the stage for a phase III study set to start this year.
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IPO money

Eikon’s $381M raise represents largest biopharma IPO in two years

Feb. 5, 2026
By Karen Carey
No Comments
Pricing the third and largest biopharma IPO of 2026, Eikon Therapeutics Inc. raised $381 million in an upsized offering of 21.18 million shares of common stock at $18 each, the high point of its price range.
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Infection

BARDA offers $100M in prize money for antiviral development

Feb. 4, 2026
No Comments
Looking to fill a treatment gap, the U.S. Biomedical Advanced Research and Development Authority (BARDA) is launching the first stage of a $100 million prize competition to support development of broad-spectrum, small-molecule antiviral therapies targeting viruses in the Togaviridae and Flaviviridae families.
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BARDA offers $100M in prize money for antiviral development

Feb. 4, 2026
No Comments
Looking to fill a treatment gap, the U.S. Biomedical Advanced Research and Development Authority (BARDA) is launching the first stage of a $100 million prize competition to support development of broad-spectrum, small-molecule antiviral therapies targeting viruses in the Togaviridae and Flaviviridae families.
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Hair loss drugmaker Veradermics floats upsized $256M US IPO

Feb. 4, 2026
By Marian (YoonJee) Chu
No Comments
Veradermics Inc. raised $256.3 million from an IPO on the New York Stock Exchange Feb. 4. The proceeds will fund three ongoing phase II/III clinical trials of VDPHL-01, its novel oral formulation of Rogaine (minoxidil) to treat pattern hair loss in men and women.
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Kim Dong-gun (DG), CEO, Elevar

Elevar gets new CEO, files NDAs for lirafugratinib, rivoceranib

Feb. 3, 2026
By Marian (YoonJee) Chu
No Comments
Elevar Therapeutics Inc. appointed Kim Dong-gun (DG) as CEO Jan. 29, as the company focuses on post-NDA strategies for lirafugratinib in bile duct cancer, and the twice-rejected rivoceranib-camrelizumab combination for liver cancer.
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Trumprx launch threatened by shutdown, kickback concerns

Feb. 3, 2026
By Mari Serebrov
No Comments
At a recent Cabinet meeting, U.S. Health and Human Services (HHS) Secretary Robert Kennedy reportedly said he expected Trumprx to probably go live within 10 days. That was Jan. 29, two days before HHS was once again forced to shut down many of its activities due to a congressional gridlock over a fiscal 2026 appropriations package to keep the department and several others open beyond Jan. 30.
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Neuromuscular illustration

NMD reports positive phase II data in Charcot-Marie-Tooth

Feb. 3, 2026
By Nuala Moran
No Comments
Following on from a successful phase IIa proof-of-mechanism study in myasthenia gravis, NMD Pharma A/S has added clinical data on a second neuromuscular disorder, reporting positive phase IIa results for ignaseclant, in both type I and type II Charcot-Marie-Tooth disease.
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