Researchers at Jiangsu Hengrui Medicine Co. Ltd., Shanghai Fourth People’s Hospital Affiliated Tongji University and Shanghai Senhui Pharmaceutical Co. Ltd. have divulged cyclopentyl adenosine derivatives reported to be useful for the treatment of chronic pain.
Researchers from Florey Neuroscience Institutes, Monash University and Olivia Newton-John Cancer Research Institute have identified fluorine-radiolabeled compounds acting as tyrosine-protein kinase Mer (MERTK) inhibitors and also as positron emission tomography (PET) imaging agents reported to be useful for the diagnosis and treatment of multiple sclerosis (MS).
The U.S. Patent and Trademark Office’s inter partes review mechanism has drawn uneven reviews in the past decade or so and Dexcom Inc. has serious misgivings about an attempt by Abbott Diabetes Care Inc. to use the process to invalidate Dexcom patents for continuous glucose monitors.
Dr. Pfleger Arzneimittel GmbH is seeking patent protection for a system and a corresponding computer program product for assisting in alleviating overactive bladder syndrome and incontinence symptoms, particularly reduction of micturitions and reduction of urine loss. The system is particularly suited for being implemented and distributed as a smartphone app which may be operated by the user.
Hinova Pharmaceuticals Inc. has divulged proteolysis targeting chimeric (PROTAC) compounds comprising a protein cereblon (CRBN) binding moiety covalently bound to an estrogen receptor (ER)-targeting moiety through a linker.
Boehringer Ingelheim Pharma GmbH & Co. KG has identified 17-β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17-β-HSD 13) inhibitors reported to be useful for the treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
GSK plc has synthesized nitrogen-containing condensed 2,3-dihydroquinazolinone compounds acting as sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of atrial fibrillation, osteoarthritis, and postoperative and neuropathic pain.
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