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BioWorld - Saturday, September 23, 2023
Home » Topics » Infection » Coronavirus

Coronavirus
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Other news to note for Aug. 23, 2023

Aug. 23, 2023
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Additional early-stage research and drug discovery news in brief, from: Hanx Biopharmaceuticals, Novavax.
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Coronavirus and DNA
Infection

Severe COVID-19 leaves epigenetic immune system memory

Aug. 22, 2023
By Mar de Miguel
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A study from Weill Cornell Medicine and The Jackson Laboratory has described the epigenetic mark SARS-CoV-2 left on immune system stem cells in the most severe cases of COVID-19 early in the pandemic, before the development of vaccines. In their work published in Cell on Aug. 18, 2023, the researchers presented a new methodology to analyze the epigenetic changes in monocytes and circulating hematopoietic stem and progenitor cells (HSPCs) that give rise to monocytes. That allowed corresponding author Steven Josefowicz and his colleagues to see if there were already changes induced by COVID-19 before HSPCs differentiated into monocytes.
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Regulatory actions for Aug. 17, 2023

Aug. 17, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Artiva, Biophytis, Bluebird, Servier, Sonnet, US Worldmeds.
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Scanning electron micrograph of a cell infected with the Omicron strain of SARS-CoV-2 virus particles
Infection

Viral alteration of mitochondrial function may trigger severe COVID-19

Aug. 14, 2023
By Mar de Miguel
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How severe a viral infection is depends on how much the virus is replicating, damaging cells as it does so, and on the response of the immune system. Or so one would think. “Some of the most severe cases of COVID-19 are happening in the absence of replicating virus,” Joseph Guarnieri told BioWorld. In work published in Science Translational Medicine on Aug. 9, 2023, Guarnieri and his colleagues have described how those severe cases unfold, even as there is no replicating virus to be found.
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Regulatory actions for Aug. 10, 2023

Aug. 10, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Futura, Georgiamune, Lemonex, Precigen, Virios.
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Vaccination
Infection

Lemonex receives approval of IND application for LEM-mR203

Aug. 10, 2023
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Lemonex Inc. announced that the IND application for its mRNA vaccine candidate LEM-mR203 has been approved by the Korean Ministry of Food and Drug Safety (MFDS) on July 21, 2023. The company plans to evaluate LEM-mR203 as potential treatment for COVID-19, with the planned phase I clinical trial being designed to assess its safety and immunogenicity in healthy adults at Seoul National University Hospital, Korea.
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SK Biocience-Novavax signing agreement

Settling debt, strengthening ties: Novavax hands 6.45% stake to SK Bioscience

Aug. 9, 2023
By Marian (YoonJee) Chu
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Novavax Inc. has signed off 6.5 million shares to SK Bioscience Co. Ltd. for an $85 million equity investment from the South Korean pharmaceutical firm, which also wrote off some of Novavax’s manufacturing liabilities, as part of their continuing vaccine alliance. Seongnam-si, South Korea-based SK Bioscience purchased Novavax shares at $13 each, reflecting a 59% premium over the 90-day trading value, to gain a 6.45% stake in the Gaithersburg, Md.-based mRNA vaccine company, an SK Bioscience spokesperson confirmed to BioWorld.
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In the clinic for Aug. 9, 2023

Aug. 9, 2023
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Clinical updates, including trial initiations, enrollment status and data readouts and publications: Aim, Algernon, Bioxytran, Bright Minds, Cocrystal, Halia, Lexicon, Maia, Meissa, Monopar, Nasus, Nervgen, Novo Nordisk, Oculis, Palatin, Praxis, Telix, Urogen, Viracta.
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Infection

Simcere Zaiming Pharmaceutical defines 3CL protease inhibitor for COVID-19 infections

Aug. 9, 2023
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Simcere Zaiming Pharmaceutical Co. Ltd. has divulged 3C-like proteinase (3CLpro) (SARS-CoV-2) inhibitors reported to be useful for the treatment of respiratory tract infections.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Infex Therapeutics nominates new lead pan-coronavirus antiviral candidate

Aug. 9, 2023
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Researchers from Infex Therapeutics Ltd. have announced the nomination of a clinical candidate for its in-house developed COV-X program. The novel first-in-class small molecule is an oral pan-coronavirus papain-like protease (PLpro) inhibitor, which was selected based on preclinical data that demonstrated in vivo efficacy of the candidate a murine model of SARS-CoV-2.
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