Reduced expression of nuclear factor erythroid 2-related factor 2 (Nrf2) is observed in humans and animal models of Alzheimer’s disease (AD), with its activation being a promising therapeutic approach.
Gb Sciences Inc. has received promising preclinical results in an interim report from a study using its plant-based compounds in preclinical zebrafish models of stress at the National Research Council of Canada (NRC).
Enveric Biosciences Inc. has nominated EB-373 as the lead development candidate to emerge from its EVM201 program. EB-373 is under development for the treatment of anxiety disorders.
RNA binding fox-1 homologue 1 (RBFOX1) is a splicing factor that regulates alternative splicing and modulates the expression of several genes involved in brain development, and it is among the top identified loci related to psychiatric disorders.
Researchers from Astellas Pharma Inc. presented preclinical data for the novel 5-HT5A receptor antagonist, ASP-5736, being developed for the treatment of fragile X syndrome (FXS).
Standigm Inc. has identified new phenylaminopyrimidine leucine-rich repeat kinase 2 (LRRK2; Dardarin) (G2019S mutant) inhibitors reported to be useful for the treatment neurodegeneration, among other disorders.
Neurocrine Biosciences Inc. has described new vesicular monoamine transporter 2 (VMAT2) inhibitors reported to be useful for the treatment of neurological and psychiatric disorders, among others.
University of Calgary scientists described their work on a small peptide aptamer 8 to bind cellular prion protein and prevent its binding with β-amyloid oligomers, an interaction that activates tyrosine-protein kinase Fyn and neuroinflammation.
Recent studies have pointed to the role of GPR39 expression in antidepressant treatment, but little is known about the interactions between specific receptors.
mPGES-1 is overexpressed in the dopaminergic neurons of the substantia nigra pars compacta of post-mortem brain tissue from patients with Parkinson’s disease (PD) as well as in 6-hydroxydopamine (6-OHDA)-injected PD mice.
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