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Home » Topics » BioWorld Science, Neurology/psychiatric

BioWorld Science, Neurology/psychiatric
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Light micrograph of skeletal muscle.
Musculoskeletal

Satellos’ AAK1 inhibitor regenerates muscle in dogs

Oct. 11, 2024
Satellos Bioscience Inc. has developed and presented data for a compound that targeted the process of muscle regeneration based on modulation of satellite stem cell polarity.
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Illustration of neurons with Lewy bodies
Neurology/psychiatric

Lewy bodies do not feed only on synuclein in Parkinson’s disease

Oct. 11, 2024
By Mar de Miguel
To recreate in the laboratory the formation of Lewy bodies as they would occur in a Parkinson’s patient, two ingredients are required: the protein α-synuclein and the participation of the immune system. The results could prevent the development and progression of this neurodegenerative disorder and help in the search for new therapies.
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Neurology/psychiatric

Haisco Pharmaceutical patent describes Nav1.8 channel blockers for pain

Oct. 10, 2024
Haisco Pharmaceutical Group Co. Ltd. has disclosed new tetrahydrofuran derivatives acting as sodium channel protein type 10 subunit alpha (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain.
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Neurology/psychiatric

SYT4 expression is needed for axonal regeneration after spinal cord injury

Oct. 10, 2024
Axonal regrowth is a crucial process for forming a compensatory neuronal network after spinal cord injury (SCI), but this is very limited in the adult mammalian central nervous system.
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Illustration of motor neuron connecting to muscle fiber
Musculoskeletal

ENTR-601-45 restores dystrophin in Duchenne muscular dystrophy models

Oct. 10, 2024
Duchenne muscular dystrophy is a severe and progressive disorder caused by mutations in the dystrophin (DMD) gene that lead to malfunction or absence of dystrophin. This protein stabilizes the sarcolemma and protects muscle cells during contraction.
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Neurology/psychiatric

Atai Therapeutics reports 5-HT2A receptor agonists

Oct. 9, 2024
Atai Therapeutics Inc. has identified 3-alkylamine indole compounds acting as 5-HT2A receptor agonists and reported to be potentially useful for the treatment of anxiety, eating and neurological disorders.
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Neurology/psychiatric

HDAC6 inhibitors described in Miralinc Pharma patent

Oct. 9, 2024
Miralinc Pharma Inc. has patented new heterocyclic selective histone deacetylase 6 (HDAC6) inhibitors reported to be useful for the treatment of type 2 Charcot-Marie-Tooth disease and chemotherapy-induced peripheral neuropathy, among others.
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Neurology/psychiatric

Humanwell Pharmaceutical US discloses new SIGMAR1 antagonists

Oct. 9, 2024
Humanwell Pharmaceutical US Inc. has synthesized new sigma non-opioid intracellular receptor 1 (SIGMAR1) antagonists reported to be useful for the treatment of cancer, pain, psychosis and substance abuse and dependence.
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Neurology/psychiatric

Lipin-1 decline promotes axonal regeneration after spinal cord injury

Oct. 9, 2024
The central nervous system (CNS) in adult mammals has limited regeneration capacity, and traumatic injuries to the CNS usually lead to permanent functional impairment.
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Neurology/psychiatric

Centessa’s orexin OX2 receptor agonist promotes wakefulness in marmosets

Oct. 9, 2024
Centessa Pharmaceuticals plc recently detailed the discovery and preclinical characterization of a novel potent and selective orexin OX2 receptor agonist, ORX-142.
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