Senescence of lung epithelial tissue translates into fibrinolysis reduction and loss of tissue repair, both drivers of pulmonary fibrotic diseases. Researchers from Tokushima University reported on the effect of ARV-825, a BRD4 degrader, as an antifibrotic agent in lung fibrosis.

Additional early-stage research and drug discovery news in brief.

In accordance with the publishing schedule, BioWorld Science was not published on Monday, Sept. 11, 2023.

Additional early-stage research and drug discovery news in brief, from: Blue Earth, Sling.

Pivalent Therapeutics Inc. has reported the development of phosphatidylinositol 3-kinase α (PI3Kα) (H1047R mutant) inhibitors.

ATP-dependent RNA helicase A (DHX9) inhibitors have been reported in an Accent Therapeutics Inc. patent as potentially useful for the treatment of cancer.

A Duke Street Bio Ltd. patent details new poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1) inhibitors reported to be useful for the treatment of cancer.

Researchers at Lucy Therapeutics Inc. have identified new adenosine receptor agonists...