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BioWorld - Tuesday, May 19, 2026
Breaking News: Bundibugyo is harsh reminder of need for broad vaccine strategiesBreaking News: Bundibugyo is harsh reminder of need for broad vaccine strategiesBreaking News: Bundibugyo is harsh reminder of need for broad vaccine strategies
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Gastrointestinal system with ulcerative colitis.
Gastrointestinal

Mage Biologics receives investment to develop oral monoclonal antibody targeting ulcerative colitis

July 21, 2023
Newly formed Mage Biologics Inc. is set to receive investment of $28 million from TVM Capital Life Science and Tillotts Pharma AG. Mage plans to advance to clinical proof of concept a novel, orally administered, humanized monoclonal antibody (MAb) for an initial indication of ulcerative colitis.
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Neurology/Psychiatric

PRX-123, a dual Aβ/tau peptide vaccine that clears Aβ plaques in brains of AD mice

July 21, 2023
Since both amyloid-β (Aβ) and tau are involved in the progression of Alzheimer’s disease (AD), it is believed that simultaneous disruption of these...
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A person receives the seasonal influenza vaccine.
Infection

MDCK-QIV influenza virus vaccine demonstrates safety and efficacy in preclinical setting

July 21, 2023
Researchers from Wuhan Institute of Biological Products Co. Ltd. and affiliated organizations presented preclinical data for the novel Madin...
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Cross section of brain
Neurology/Psychiatric

ATH-1105 protects from TDP-43 protein pathology in preclinical models

July 21, 2023
There is a strong link between the loss of TAR DNA-binding protein 43 (TDP-43) function and the development of frontotemporal dementia (FTD)...
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Cancer

Microbiome member has sex-specific effects in colorectal cancer

July 21, 2023
By Marian (YoonJee) Chu
Researchers from the Chinese University of Hong Kong have identified the Carnobacterium maltaromaticum bacterium as a potential oral probiotic prophylactic to increase vitamin D production and reinvigorate gut microbiota to prevent colorectal cancer (CRC) in women.
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3D illustration of a eukaryotic cell
Neurology/Psychiatric

Loss of contact between mitochondria and lysosomes contributes to genetic Parkinson’s disease

July 21, 2023
By Helen Albert
Researchers based at Northwestern University Feinberg School of Medicine have discovered that a lack of contact between mitochondria and lysosomes in the cells of patients with a genetic form of Parkinson’s disease likely contributed to their symptoms.
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Other news to note for July 20, 2023

July 20, 2023
Additional early-stage research and drug discovery news in brief, from: Biomica, Tempest Therapeutics.
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Infection

Fujian Akeylink Biotechnology identifies new Mpro inhibitors for SARS-CoV-2 infection

July 20, 2023
Fujian Akeylink Biotechnology Co. Ltd. has prepared short peptide compounds containing β-aminoketone and characterized as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors.
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Cancer

New Mat2A inhibitors described in Shanghai Haihe Biopharma patent

July 20, 2023
Work at Shanghai Haihe Biopharma Co. Ltd. has led to the development of pyrimidine-2(1H)-one-fused bicyclic compounds acting as S-adenosylmethionine synthase isoform type-2 (Mat2A) inhibitors and thus reported to be useful for the treatment of cancer.
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Cancer

Boehringer Ingelheim patents KRAS G12C mutant inhibitors for the treatment of cancer

July 20, 2023
Boehringer Ingelheim Pharma GmbH & Co. KG has prepared and tested heteroaromatic compounds described as GTPase KRAS G12C mutant inhibitors and reported to be useful for the treatment of cancer.
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