Breast cancer (BC) is a prevalent form of cancer among women globally. Recent studies suggest that circular RNA (circRNA) plays a significant role in BC progression, but the biological functions and underlying mechanisms remain unexplored. According to a recent study published in the Journal of Translational Medicine, the interaction between circDNAJC11 and TATA-box-binding protein-associated factor 15 (TAF15) promotes BC progression through the upregulation of MAPK6 expression and activation of the MAPK signaling pathway.
New research has shed light on a molecular mechanism that fuels inflammation in acute lung injury (ALI), a severe and often fatal condition. Macrophage necroptosis, a form of cell death, is a necessary process contributing to intrapulmonary inflammation during ALI. However, the molecular mechanism that initiates macrophage necroptosis has remained unclear until now.
Researchers from the National Institutes of Health recently presented preclinical data for the dopamine D3 receptor antagonist VK-4-116, which has potential for the treatment of opioid use disorder (OUD).
Restoring levels of the immune modulator mesencephalic astrocyte-derived neurotrophic factor (MANF) in the muscles of aged animals improved their regenerative capacity by promoting repair-associated injury responses, researchers from the University of Lisbon have discovered.
Base editing (BE), a technique that modifies a single nucleotide in living cells, has been successfully tested to resolve the CD3δ mutation in severe combined immunodeficiencies (SCIDs) and produce functional T cells. For now, scientists at the University of California, Los Angeles (UCLA), completed the study on patient stem cells and artificial thymic organoids, shortening the way for future clinical trials.
The AMP-activated protein kinase (AMPK) is a sensor of metabolic stress and a key mediator in preserving metabolic homeostasis both at the cellular and organism levels. AMPK activation is considered a targetable mechanism for diseases associated with metabolic perturbations, such as diabetes, obesity, fatty liver disease and cancer, among others. However, the regulators of AMPK that antagonize AMPK activators remain unknown, although they are critical to efficiently target AMPK activation for therapeutic purposes.
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