Autophagy plays a critical role in the regulation of skeletal muscle integrity; however, the molecular mechanisms regulating autophagy are not fully understood. In a recently published study, researchers from McGill University Health Centre and affiliated organizations aimed to investigate these mechanisms and identify novel regulators of autophagy and skeletal muscle integrity.
Kaken Pharmaceutical Co. Ltd. and Bitbiome Inc. have entered into an agreement to collaborate on the creation of new drugs targeting infectious diseases with unmet medical needs.
Researchers at Indiana University Bloomington have developed allosteric modulators of the opioid receptor that were superior to the opioid antidote naloxone at blocking the effects of fentanyl in vitro. They presented their work in a session on “Progress towards more efficacious medicine: Antibiotics and antidotes” at the 2023 spring meeting of the American Chemical Society (ACS).
Secreting cytokines and killing tumor cells can be stressful for a T lymphocyte. In short adverse circumstances, these cells adapt to acute stress. If the situation persists, they activate a chronic stress response mechanism. According to a study by the Institute for Biomedical Research (IRB) in Barcelona, the cytoplasmic polyadenylation element-binding protein 4 (CPEB4) mediated this adaptation process.
Spark Biopharma Inc. has prepared and tested stimulator of interferon genes protein (STING; TMEM173) agonists that are reported to be useful for the treatment of cancer.
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13; LZK) inhibitors reported to be useful for the treatment of cancer have been described in a recent U.S. Department of Health and Human Services patent.
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