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BioWorld - Monday, June 29, 2026
Breaking News: Science fiction realized: BCI tech is hereBreaking News: FDA says yes to Viridian’s Lumvoa in TEDBreaking News: Science fiction realized: BCI tech is here
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Respiratory

Roche discovers new PDK1 inhibitors

Dec. 15, 2022
Roche has synthesized pyruvate dehydrogenase kinase 1 (PDK1) inhibitors reported to be useful for the treatment of systemic lupus erythematosus, psoriasis, inflammatory bowel diseases, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cancer.
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Cancer

Blossomhill Therapeutics presents new GTPase KRAS mutant inhibitors

Dec. 15, 2022
Blossomhill Therapeutics Inc. has identified macrocyclic compounds acting as GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Nucmito Pharmaceuticals describes new compounds for cancer

Dec. 15, 2022
Nucmito Pharmaceuticals Co. Ltd. has disclosed indene derivatives reported to be useful for the treatment of cancer and fibrosis.
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Neurology/Psychiatric

Sun Yat-Sen University patents new antidepressants

Dec. 15, 2022
Sun Yat-Sen University has divulged pyrimidodiazepanone compounds reported to be useful for the treatment of depression.
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Neurology/Psychiatric

Researchers develop new model of tuberous sclerosis complex-associated epilepsy

Dec. 15, 2022
Tuberous sclerosis complex (TSC) is a multisystemic disorder caused by loss-of-function mutations in the TSC1 or TSC2 genes. Its clinical phenotype is heterogenous, but most patients with TSC have epilepsy.
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Lab glassware and scientist
Neurology/Psychiatric

Qrons to explore Tellurium-based compounds with QS-200 for concussion, infection and sepsis

Dec. 15, 2022
Qrons Inc. has established a collaboration with scientists at a public research university in Israel, by which Tellurium-based compounds in combination with Qrons' QS-200 product candidate and other configurations will be explored as treatment for diffused axonal injuries (concussions), which accounts for approximately 89% of traumatic brain injuries (TBIs).
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Colorized transmission electron micrograph of rabies virus.
Infection

Everest achieves preclinical proof-of-concept milestone for its mRNA rabies vaccine

Dec. 15, 2022
Everest Medicines Ltd. has achieved a preclinical proof-of-concept milestone for its mRNA rabies vaccine program. This new vaccine candidate for rabies post-exposure prophylaxis was developed in partnership with Providence Therapeutics Holdings Inc. utilizing a clinically validated mRNA technology platform.
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Brain
Neurology/Psychiatric

SRI-32743, an allosteric modulator that attenuates cocaine and Tat binding to DAT

Dec. 15, 2022
The HIV regulatory protein transactivator of transcription (Tat) is a viral protein believed to play a key role in the neurotoxicity and cognitive impairment seen in HIV-associated neurocognitive disorders. Tat allosterically modulates dopamine (DA) reuptake through the human DA transporter (hDAT). In the current study, researchers from University of South Carolina and affiliated organizations aimed to assess the effects of the novel allosteric modulator of DAT, SRI-32743, on the Tat-DAT interaction.
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Multiple sclerosis
Neurology/Psychiatric

Abata selects autologous Treg therapy ABA-101 as development candidate for progressive MS

Dec. 15, 2022
Abata Therapeutics Inc. has selected its first development candidate, ABA-101, an autologous regulatory T cell (Treg) therapy for the treatment of progressive multiple sclerosis (MS). ABA-101 targets MS patients with nonrelapsing progressive disease who have a DRB1*15:01 genetic haplotype and for whom imaging evidence of ongoing inflammatory tissue injury has been observed.
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Neurology/Psychiatric

CRISPR/Cas9-based removal of a repeat expansion in C9ORF72 counteracts disease mechanisms

Dec. 15, 2022
The hexanucleotide repeat expansion (HRE) GGGGCC in the noncoding region of the chromosome 9 open reading frame 72 (C9ORF72) gene is the most common cause of hereditary (40%) and apparently sporadic (5%-6%) amyotrophic lateral sclerosis (ALS).
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