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BioWorld - Sunday, July 19, 2026
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Immuno-oncology

Arbutus Biopharma identifies new PD-L1 antagonists

Oct. 28, 2022
Arbutus Biopharma Corp. has described programmed cell death 1 ligand 1 (PD-L1) antagonists reported to be useful for the treatment of cancer, hepatitis B and hepatitis D viral infection.
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Infection

Pfizer discloses new 3CLpro viral inhibitors for COVID-19 treatment

Oct. 28, 2022
Pfizer Inc. has divulged 3C-like proteinase (3CLpro) (SARS-CoV-2) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Cancer

Genfleet Therapeutics patents new MAP4K1 inhibitors

Oct. 28, 2022
Genfleet Therapeutics Inc. has divulged amine-substituted pyridine fused-ring compounds acting as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) inhibitors reported to be useful for the treatment of cancer.
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Immune checkpoint inhibitors illustration of PD-1, CTLA-4 and PD-L1.
Immuno-oncology

FDA approves IND for bifunctional fusion protein SIM-0237

Oct. 28, 2022
Simcere Pharmaceutical Group announced that the FDA has cleared the company’s IND application for SIM-0237 for the treatment of adult patients with advanced solid tumors.
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Mantle cell lymphoma
Cancer

KAN-571 demonstrates efficacy in preclinical models of mantle cell lymphoma

Oct. 28, 2022
Kancera AB has reported new preclinical data for its ROR1 inhibitor KAN-571, being developed for the treatment of mantle cell lymphoma (MCL).
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Immuno-oncology

SYS-6002 receives clinical trial approval in China

Oct. 28, 2022
CSPC Pharmaceutical Group Ltd. announced that the National Medical Products Administration of the People’s Republic of China has granted approval to conduct clinical trials of the company’s antibody-drug conjugate candidate, SYS-6002.
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Cancer

Preclinical studies support use of TAS-1440 in combination with anti-PD-1 antibodies for treatment of immunotherapy-resistant cancer

Oct. 28, 2022
Lysine-specific demethylase 1A (LSD1) is a monoamine oxidase encoded by the KDM1A...
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DNA illustration
Biomarkers

Pathogenic ELOC gene variants as a novel cause for VHL disease

Oct. 28, 2022
To date, only inactivating germline variations in the VHL gene have been linked to von Hippel-Lindau...
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Cancer

I-0436650, a potent and selective SHP2 allosteric inhibitor for solid tumor treatment

Oct. 28, 2022
Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) is a target for cancer...
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Illustration of human papillomavirus (HPV) infection
Infection

Clinical trial application for adjuvanted recombinant quadrivalent HPV vaccine accepted in China

Oct. 28, 2022
Jiangsu Recbio Technology Co. Ltd. announced that it has received a notice of acceptance from...
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