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Cancer

99mTc-FGF2 is a novel theragnostic compound for early-stage cancer

Oct. 25, 2022
Recent evidence suggested fibroblast growth factors (FGF) to be involved in epithelium-mesenchymal transition (EMT) and cancer progression.
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Antibodies attacking SARS-CoV-2 virus
Infection

Discovery of novel broadly neutralizing MAb against SARS-CoV-2

Oct. 25, 2022
Researchers from Emory University have discovered a novel broadly neutralizing SARS-CoV-2 antibody, 002-S21F2, being developed as a potential anti-coronavirus therapeutic.
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Woman in crowd with anxiety
Neurology/Psychiatric

Enveric nominates psilocin prodrug EB-373 as lead candidate for anxiety disorders

Oct. 25, 2022
Enveric Biosciences Inc. has nominated EB-373 as the lead development candidate to emerge from its EVM201 program. EB-373 is under development for the treatment of anxiety disorders.
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Diagnostics

Discovery of novel copper-64-labeled small molecule-based radiotracers for PD-L1 PET imaging

Oct. 25, 2022
Researchers from Helmholtz-Zentrum Dresden-Rossendorf presented the discovery of novel small molecule-based radiotracers for PD-L1 PET or SPECT imaging.
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A young C. elegans adult
Genetic/Congenital

Proteostasis disruption links menopause to aging in C. elegans

Oct. 25, 2022
By Anette Breindl

Disrupted meiosis, the cell division process that leads to the production of reproductive cells in sexually reproducing organisms, led to a decline in overall health by triggering an accelerating aging signature in the roundworm Caenorhabditis elegans.

The work is “the first direct evidence that manipulating the health of reproductive cells leads to premature aging and a decline in healthspan,” senior author Arjumand Ghazi, an associate professor of pediatrics, developmental biology, and cell biology and physiology at the University of Pittsburgh and the University of Pittsburgh Medical Center (UPMC) Children’s Hospital, said in a press release.
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Other news to note for Oct. 24, 2022

Oct. 24, 2022
Additional early-stage research and drug discovery news in brief, from: Asher.
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Cancer

Medshine Discovery presents new PTPN11 inhibitors

Oct. 24, 2022
Medshine Discovery Inc. has patented selenium-containing compounds acting as tyrosine-protein phosphatase non-receptor type 11 (PTPN11) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Humanwell Healthcare divulges new Mat2A inhibitors

Oct. 24, 2022
Humanwell Healthcare (Group) Co. Ltd. has disclosed pyrimidopyrazine compounds acting as S-adenosylmethionine synthase isoform type-2 (Mat2A) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Canwell Biotech identifies new MetAP2 inhibitors

Oct. 24, 2022
A recent Canwell Biotech Ltd. patent details the discovery of methionine aminopeptidase-2 (MetAP2) inhibitors reported to be useful for the treatment of cancer, diabetes, obesity, rheumatoid arthritis and psoriasis.
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Cancer

Yiteng Pharmaceutical Industry Taizhou discloses new CDK7 inhibitors

Oct. 24, 2022
Yiteng Pharmaceutical Industry Taizhou Co. Ltd. has described cyclin-dependent kinase 7 (CDK7) inhibitors reported to be useful for the treatment of cancer.
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