Arginases play key roles in metabolic pathways. Arginase 1 (ARG1) is expressed by myeloid cells in the tumor microenvironment and suppresses the functioning of T and NK cells.
Using a two-drug combination, researchers at the University of California at San Francisco (UCSF) have been able to achieve brain-specific inhibition of several kinases.
Seoul National University has patented chaperone protein DnaK (HSP70) inhibitors acting as antineoplastic enhancing agents reported to be useful for the treatment of cancer.
A new study has unveiled the signaling cascade involved in the progression of brain metastasis from breast cancer. A family of connexins participates in the process that regulate the expression of laminins that favor metastatic cells to colonize the brain.
New and updated preclinical data presented at the Annual Congress of the European Society for Medical Oncology in Paris, including: Enlivex, GT Biopharma, Immatics, SQZ Biotechnologies.
Concentric Analgesics Inc. has discovered transient receptor potential cation channel subfamily M member 8 (TRPM8) agonists reported to be useful for the treatment of oropharyngeal dysphagia.
Biohaven Therapeutics Ltd. has divulged compounds targeting TAR DNA-binding protein 43 (TDP43) reported to be useful for the treatment of amyotrophic lateral sclerosis, traumatic encephalopathy, sporadic inclusion body myositis, frontotemporal dementia and Alzheimer's disease.
Klotho Therapeutics Inc. has synthesized new histone deacetylase 8 (HDAC8) inhibitors reported to be useful for the treatment of acute kidney injury and chronic kidney disease.
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