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Cancer

Insilico Medicine discloses new PTPN2 inhibitors

July 26, 2024
Insilico Medicine Inc. has identified compounds acting as tyrosine-protein phosphatase non-receptor type 2 (PTPN2; TCPTP) inhibitors reported to be useful for the treatment of cancer and metabolic disease.
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Cancer

MET degradation inducers described in Oncozen patent

July 26, 2024
Oncozen Co. Ltd. has patented new proteolysis targeting chimera (PROTAC) compounds comprising a heat shock protein 90 (HSP90) binding moiety covalently bound to hepatocyte growth factor receptor (HGFR; MET) targeting moiety through a linker.
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Zebrafish
Cancer

New adult zebrafish model for studying SDHB-associated phaeochromocytomas and paragangliomas

July 26, 2024
Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from chromaffin cells chromaffin cells in the adrenal medulla or extra-adrenal paraganglia, respectively.
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Sickle cell illustration
Hematologic

Actinium Pharmaceuticals obtains FDA clearance for trial of Iomab-ACT in sickle cell disease

July 26, 2024
Actinium Pharmaceuticals Inc. has received FDA clearance of an IND application to study Iomab-ACT for targeted conditioning prior to a bone marrow transplant (BMT) in patients with sickle cell disease. 
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Illustration of hookworms in foot
Infection

Novel heterocycle substituted aminamidine derivative shows potent, rapid anthelmintic activity against N. americanus

July 26, 2024
Researchers from the Chinese Center for Disease Control and Prevention detailed the discovery of novel aromatic heterocycle substituted aminamidine derivatives (AADs) for the treatment of Necator americanus infection (hookworms).
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Woman receiving chemotherapy
Cancer

Z-526 reverts chemotherapy-induced cachexia in preclinical models

July 26, 2024
Chemotherapy usually induces cachectic muscle loss through different mechanisms. Among these, oxidative stress is known to decrease protein synthesis and increase proteolysis leading to muscle atrophy.
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Child feet
Cancer

Medannex awarded funding to study therapy in pediatric osteosarcoma

July 26, 2024
Medannex Ltd. has been awarded an Innovate UK grant to fund a £313,000 (US$403,000) project developing a new treatment for pediatric osteosarcoma. Innovate UK will fund £231,000 (US$297,000) of the project costs, with the remainder financed by Medannex.
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Illustration of herpes simplex virus particles
Infection

Long-acting helicase-primase inhibitor prevents HSV recurrences

July 26, 2024
Half of the individuals with genital herpes simplex virus (HSV) infection experience several recurrence episodes per year, especially if the causative agent is HSV type 2 (HSV-2). Standard-of-care viral DNA polymerase inhibitors are not fully effective in preventing recurrences and managing symptoms.
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Cancer

SP-1-303 inhibits ER-positive breast cancer cell proliferation

July 26, 2024
Researchers from Shuttle Pharmaceuticals LLC and Georgetown University have described the in vitro and in vivo profile of SP-1-303, designed as a dual-function histone deacetylase (HDAC) inhibitor and ataxia-telangiectasia mutated protein (ATM) activator, in breast cancer models.
Read More
Liver disease
Cancer

As target organ, liver can influence which metastases take

July 26, 2024
By Mar de Miguel
Not all cancer cells that detach from the primary tumor and embark on a journey to another organ colonize it. To establish themselves, cells need specific conditions. Scientists at the Federal Institute of Technology Zurich (ETH Zurich) explored this hypothesis in the liver and identified a protein involved in metastatic transformation. Blocking it prevented liver metastasis. Their findings may have applications in other organs and various types of cancers.
Read More
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