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Immune

Genor wins $440M+ cancer drug deal with Third Rock/Two River firm

Aug. 13, 2024
By Marian (YoonJee) Chu
China’s Genor Biopharma Co. Ltd. agreed to out-license GB-261, its bispecific antibody candidate primarily targeting B-cell lymphomas, to TRC 2004 Inc., a U.S.-based newco co-founded by Third Rock Ventures LLC and Two River Group Holdings LLC.
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Cancer

University of Bradford synthesizes new duocarmycins for cancer

Aug. 13, 2024
Researchers at the University of Bradford have prepared and tested duocarmycins reported to be useful for the treatment of cancer.
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Cancer

Otsuka Pharmaceutical patents new antibody-drug conjugates

Aug. 13, 2024
Otsuka Pharmaceutical Co. Ltd. has disclosed antibody-drug conjugates comprising humanized monoclonal antibody targeting syndecan-1 (SDC1; SYND1; CD138) covalently linked to anticancer and/or cytotoxic agents through linkers reported to be useful for the treatment of cancer.
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Immune

Shanghai Zedeman Pharmaceutical Technology describes new AhR agonists

Aug. 13, 2024
Shanghai Zedeman Pharmaceutical Technology Co. Ltd. has identified aryl hydrocarbon receptor (AhR) agonists reported to be useful for the treatment of autoimmune disease, cancer, diabetes, eye disorders, viral infections, psoriasis, and inflammatory and neurological disorders, among others.
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Cancer

Zeno Management discovers GTPase KRAS mutant inhibitors

Aug. 13, 2024
Zeno Management Inc. has divulged GTPase KRAS (mutant) inhibitors (particularly, KRAS (G12C mutant)) reported to be useful for the treatment of cancer.
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Cancer

Aligos Therapeutics presents new PD-1/PD-L1 interaction inhibitors

Aug. 13, 2024
Aligos Therapeutics Inc. has described programmed cell death 1 (PDCD1; PD-1; CD279)/PD-1 ligand 1 (PD-L1; CD274) interaction inhibitors reported to be useful for the treatment of liver cancer (hepatocellular carcinoma) and hepatitis B.
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Pill in immersive interface
Immune

Deepcure selects DC-9476 for autoimmune diseases

Aug. 13, 2024
Deepcure Inc. has selected its first artificial intelligence (AI)-generated candidate, DC-9476, for autoimmune disease.
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Liver over digital lens background
Gastrointestinal

New PTP1B inhibitor ameliorates liver fibrosis in mice

Aug. 13, 2024
Liver fibrosis still lacks effective therapy; hepatic stellate cells (HSCs) are the primary fibrogenic cell type activated during liver injury. To date, almost half of the drugs used for liver treatment are natural product derivatives.
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DNA illustration
Genetic/congenital

Kano Therapeutics secures $5M seed funding

Aug. 13, 2024
Kano Therapeutics Inc. announced it has secured $5 million in seed funding, bringing its total funding to date to $7.1 million. The company plans to use the funding to begin internal pipeline development of ex vivo genetic medicines based on kilobase gene insertion, expand its existing therapeutic collaborations to initiate externally driven preclinical programs, and scale its production capacity.
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Ischemic stroke
Cardiovascular

Esculetin promotes stroke rehabilitation by inhibiting CKLF1

Aug. 13, 2024
Esculetin, also known as 6,7-dihydroxycoumarin, is a coumarin-derived phytochemical that has shown effects against ischemic stroke. Additionally, chemokine-like factor 1 (CKLF1) has been revealed in previous findings to be a target for stroke when using coumarin-derived compounds. The effects of esculetin and the potential involvement of CKLF1 were tested in photothrombotic stroke in mice.
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