Chongqing Fuan Pharmaceutical (Group) Co. Ltd. has prepared and tested class of 7-((5-membered heterocyclic)methyl)-8-carboxylic acid-benzo cyclic borate derivatives reported to be useful for the treatment of bacterial infections.
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) caused by nerve inflammation that affects over 2 million people globally. Bromodomain and extra-terminal domain (BET) proteins, containing BD1 and BD2 bromodomains, are among the proteins dysregulated in MS.
Researchers from Lanzhou University have described the discovery and preclinical evaluation of new multifunctional opioid agonists being developed as potential antinociceptive agents.
Acute myeloid leukemia (AML) presents high recurrence and low survival rates due to drug resistance and different gene mutations that contribute to the difficulty of being cured. Cyclin-dependent kinase 8 (CDK8) is a key oncogenic driver in AML and thus considered a therapeutic target worth exploring.
Burn injuries, including those induced by chemicals, may have systemic effects, and can lead to acute lung injury (ALI). Chemical burn injuries account for about 2% to 5% of total skin burn injuries. Among the chemicals, vesicating agents like Lewisite are particularly relevant due to the lack of antidotes.
Researchers from China Medical University (Taiwan) and affiliated organizations have published results from a study that aimed to identify generic variants within the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway that could represent novel biomarkers in patients with prostate cancer.
Acepodia Inc. has obtained FDA clearance of its IND application for ACE-2016, an allogeneic γδ2 T-cell therapy for the treatment of epidermal growth factor receptor (EGFR)-expressing malignancies in patients with solid tumors.
Although several mouse models have been developed to investigate the mechanisms underlying Alzheimer’s disease (AD), most of them are transgenic and, therefore, present disadvantages in terms of costs and time constraints. To overcome these limitations and develop a more cost-effective and reliable animal model, a team of researchers from JSS Academy of Higher Education & Research and collaborators recently proposed a novel pharmacological AD model in zebrafish using aluminum chloride (AlCl3).
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