Chengdu Brilliant Pharmaceutical Co. Ltd. and Chengdu Xinke Pharmaceutical Co. Ltd. have disclosed drug conjugates comprising a bone-targeting moiety covalently bound to a radiolabeled-chelating agent through a linker acting as positron emission tomography (PET)/single-photon emission computerized tomography (SPECT) imaging agents. They are reported to be useful for diagnosis and treatment of bone disorders.
The United Bio-Technology (Hengqin) Co. Ltd. has reported compounds acting as glucagon-like peptide 1 receptor (GLP-1R) agonists. They are reported to be useful for the treatment of diabetes type 1, gout, psoriasis, stroke, inflammatory bowel disease, hyperlipidemia, and Alzheimer’s and Parkinson’s disease, among others.
Researchers from the University of Oxford and the Health Research Institute La Fe (Spain) investigated the potential of multigene RNA-based therapeutics in Alzheimer’s disease, aiming to overcome potential compensatory mechanisms and patient heterogeneity.
A recent publication in Cell Reports Medicine from researchers at the Washington University School of Medicine and the La Jolla Institute for Immunology presents a promising new strategy for H5N1 vaccination.
Solute carrier family 2, member 5 (GLUT5) is known to be upregulated in metabolic disorders and cancer, but its potential role in ischemic stroke is not well defined. Japanese researchers have now explored the association of GLUT5 expression with oxidative stress in ischemic stroke.
Effective targeted therapies against aggressive breast cancer subtypes, such as triple-negative breast cancer (TNBC), are still lacking. Developing therapeutics targeting nonenzymatic, intracellular proteins with causal roles in TNBC progression remains a significant challenge.
Affinia Therapeutics Inc. has obtained IND clearance from the FDA for AFTX-201, an investigational genetic medicine for the treatment of BAG3-associated dilated cardiomyopathy (DCM). The phase I/II UPBEAT trial will begin in the first half of this year.
DNA polymerase θ (POLθ) is a specialized, error-prone DNA polymerase that promotes the repair of DNA double-strand breaks through theta-mediated end joining (TMEJ), an alternative pathway that operates independently of homologous recombination.
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